Results 31 to 40 of about 369,420 (269)
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
EconomiesThis study delves into the intricate relationship between corporate innovation and public support, underscoring innovation’s vital role in driving economic growth and competitiveness.
Cátia Rosário +2 more
doaj +1 more source
The Economics of Small States; Observations from Scotland - a Comment
Welsh Economic Review, 2016 The historical perspective provided by John Kay in his article presents a compelling rationale for re-thinking what a state is and what it should do. The production relationships and consumption patterns that characterise today’s interconnected global ...
James R. Wilson
doaj +1 more source
The Inner Functioning of Local Governance Networks in Centralized Countries: A ‘Brave New World’?
Social Sciences, 2023 Local governance networks are increasingly seen as the big idea to cope with issues that are complex enough in scope and scale to require a diversity of expertise and resources. While conventional narrative has posited that local networks are optimal for
Patrícia Silva +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
The Lancet Planetary HealthBackground: Green education is an essential precursor to promoting long-term sustainable practices and fostering environmentally conscious behaviours, especially among the younger generations.
Hui Hui Teow, PhD +3 more
doaj +1 more source
The comparative economic analysis of Hungarian and German apple production of good standard
International Journal of Horticultural Science, 2009 The profitability of the Hungarian apple production considering firms producing on high standard is not lagged behind significantly from that of German firms, moreover in certain cases it reflects a more positive situation.
F. Apáti
doaj +1 more source
Smooth transition regression model relating inflation to economic growth in Tunisia
Journal of Economic Structures, 2023 Since its independence, Tunisia has embarked on monetary and financial sector reforms aimed at boosting economic growth. However, these reforms have not been effective due to inflation pressures in this country.
Hamdi Becha, Maha Kalai, Kamel Helali
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis
Molecular Oncology, EarlyView.LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini +1 more
wiley +1 more source