Results 81 to 90 of about 1,236,352 (345)
Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs
Molecular Oncology, EarlyView.In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza +3 more
wiley +1 more source
Journal of Entrepreneurship, Management and Innovation, 2014 More and more, the ability to innovate can be considered as an explanatory factor in determining the long-term potential of firms to be competitive.
Henar Alcalde Heras
doaj +1 more source
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
(Re)-structuring the Ceo’s compensation—the case of Israel
Economics and Business Review, 2020 The executive compensation issue continues to cause protest due to the increasing number of cases of an unjustifiably high level of pay. The main conflict arises from the misalignment of interests between the short-term expectations of the manager and ...
Mroczek-Dąbrowska Katarzyna +1 more
doaj +1 more source
Political Competitiveness [PDF]
Political competitiveness – which many interpret as the degree of democracy – can be modeled as a monopolistic competition. All regimes are constrained by the threat of "entry," and thereby seek some combination of popular support and political entry ...
Casey B. Mulligan, Kevin K. Tsui
core
Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, EarlyView.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source
Dendrometer as a water stress indicator for apple trees
Agricultural Water ManagementThe use of dendrometers to measure the stem diameter (SD) of trees provides information about their actual water stress levels. The Scholander chamber is currently the gold standard for measuring stem water potential and thus for quantifying the water ...
Thainná Waldburger +6 more
doaj +1 more source
Basque Country cluster policy: the road of 25 years
Regional Studies, Regional Science, 2017 This paper addresses how cluster policy, particularly its management part, contributes to the processes of switching path dependency and escaping lock-ins in the old industrial regions.
Anastasiia Konstantynova
doaj +1 more source
How Competitive Are State Insurance Markets? [PDF]
, 2011 Assesses the competitiveness of state health insurance markets for individuals and small groups. Explains how market competitiveness will affect state policy decisions on insurance exchange design, new market rules, and rate ...
core
FEBS Open Bio, EarlyView.Phenotypic plasticity in a newly established set of EGFR inhibitor‐adapted NSCLC cell lines during adaptation and in established cell lines. Here, we introduce novel sublines of the EGFR‐mutant non‐small cell lung cancer (NSCLC) cell lines HCC827 and HCC4006 adapted to the EGFR kinase inhibitors gefitinib (HCC827rGEFI2μm, HCC4006rGEFI1μm), erlotinib ...
Tharsagini V. Nanthaprakash +6 more
wiley +1 more source