Results 41 to 50 of about 97,746 (259)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Managing in an economic crisis: The role of market orientation in an international law firm [PDF]

, 2013
This research paper contributes to the understanding of the relationship between market orientation and performance in the context of a law firm during a time of economic crisis.
Appiah-Adu, Atuahene-Gima, Baruch, Bhuian, Cano, Carrillat, Churchill, Day, Day, Deng, Deshpandé, Elg, Elg, Ellis, Esteban, Fiona Lettice, Gounaris, Grewal, Grinstein, Harris, Hitt, Homburg, Homburg, Hult, Ingo Forstenlechner, Jaworski, Kara, Kirca, Kline, Kohli, Kohli, Langerak, Maister, Markus Tschida, Matsuno, Matsuno, Mergermarket, Miles, Muzio, Müller-Stewens, Naidoo, Narver, Nunnally, Ottesen, Parsons, Pearson, Pulendran, Reihlen, Rogers, Ruekert, Schlosser, Scott, Selnes, Shapiro, Shoham, Siguaw, Singh, Slater, Slater, Slater, Teddlie, Van Egeren, Van Raaij, Vickerstaff, Webster, Workman, Yin   +66 more
core   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

The Practice Of Strategic Management Accounting In Public Sector Indonesia

Jurnal Akuntansi
Market orientation, cost leadership strategies, strategic management accounting practices, competitor accounting, and customer accounting of village-owned enterprises in Indonesia were the focus of this study's effort to identify empirical evidence of a ...
Sriyono, Mohamad Irhas Effendi, Afni Sirait   +2 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Strategic Orientation and Marketing Capabilities [PDF]

مطالعات مدیریت راهبردی, 2013
The purpose of this study is to investigate the influence of strategic orientation on the marketing capabilities in the organization. The nature of research method is survey-applied. For data gathering, the managers of Mellat bank in Mashhad were subject
Fariborz Rahimnia, Azar Kaffashpoor, malihe pourreza   +2 more
doaj  

INFLUENCE OF MARKET ORIENTATION AND CROSS-FUNCTIONAL COLLABORATION ON EXPORT PRODUCT ADAPTATION STRATEGY AND EXPORT MARKETING PERFORMANCE [PDF]

Russian Journal of Agricultural and Socio-Economic Sciences, 2022
The study of Export Marketing Performance becomes very important after the export trade world was affected by the Covid-19 pandemic in 2020 and 2021. Meanwhile, high global inflation resulted in the weakening of global people's purchasing power in the ...
Naparin M., Helmi M.
doaj  

Study of E. coli Hfq's RNA annealing acceleration and duplex destabilization activities using substrates with different GC-contents [PDF]

, 2012
Folding of RNA molecules into their functional three-dimensional structures is often supported by RNA chaperones, some of which can catalyse the two elementary reactions helix disruption and helix formation.
Beich-Frandsen, Mads, Doetsch, Martina, Fürtig, Boris, Lybecker, Meghan, Saxena, Krishna, Schroeder, Renée, Stampfl, Sabine   +6 more
core   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source