Results 31 to 40 of about 97,746 (259)
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
The effect of market orientation on performance efficiency of the hotel industry
تحقیقات بازار یابی نوین, 2014 This research assesses how the value of the customer perspective, market orientation and competitive advantages will affect organizational efficiency in hotel industry.
Bahram Kheiri +2 more
doaj
Cogent Business & Management, 2019 The study assessed the impact of market orientation on performance of small and medium enterprises (SMEs); the mediating role of innovation. The study was conducted on a total of 500 SMEs out of which 391 responses were received representing 78.2 ...
Bylon Abeeku Bamfo, Jerry Jay Kraa
doaj +1 more source
An examination of firms’ strategic orientations, innovativeness and performance with large Korean companies [PDF]
Asia Pacific Journal of Innovation and Entrepreneurship, 2017 Purpose - This paper aims to provide an examination of firms’ strategic orientations, innovativeness and performance with large Korean companies.
Sohyoun Synthia Shin, Sungho Lee
doaj +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Competitor-oriented Objectives: The Myth of Market Share [PDF]
, 2005 Competitor-oriented objectives, such as market-share targets, are promoted by academics and are commonly used by firms. A 1996 review of the evidence, summarized in this paper, indicated that competitor-oriented objectives reduce profitability.
Armstrong, J. Scott, Green, Kesten C.
core +2 more sources
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Exploring the link between market orientation and innovation in the European and US insurance markets [PDF]
, 1998 Despite the increasing research importance of market orientation concept in the marketing literature, few comparative studies between Europe and U.S. have been conducted.
Lado, Nora, Maydeu Olivares, Alberto
core +1 more source