Results 61 to 70 of about 9,857 (260)

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

open access: yesFEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui   +10 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

open access: yesFEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke   +4 more
wiley   +1 more source

PENGARUH ORIENTASI PASAR TERHADAP KINERJA EKSPOR SUMATERA BARAT

open access: yesEconomica, 2012
International trade theories are merely explaining several private business units. Therefore, the development of international trade theories has emerged.
yola malinda
doaj   +1 more source

Competitor Orientation: Effects of Objectives and Information on Managerial Decisions and Profitability

open access: yesJournal of Marketing Research, 1996
Managers are often advised, “beat your competitors,” which sometimes contrasts with the advice, “do the best for your firm.” This may lead managers to focus on comparative measures such as market share. Drawing on game theory, the authors hypothesize that managers are competitor oriented under certain conditions, in particular, when they are provided ...
Armstrong, J. Scott, Collopy, Fred
openaire   +3 more sources

Cognitive Status in People With Epilepsy in the Republic of Guinea: A Prospective, Case–Control Study

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective People with epilepsy (PWE) may experience cognitive deficits but fail to undergo formal evaluation. This study compares cognitive status between PWE and healthy controls in the West African Republic of Guinea. Methods A cross‐sectional, case–control study was conducted in sequential recruitment phases (July 2024–July 2025) at Ignace ...
Maya L. Mastick   +14 more
wiley   +1 more source

An Appraisal of the Impact of Market Orientation Dimensions on Knowledge Management Functions [PDF]

open access: yesمدیریت راهبردی دانش سازمانی, 2018
The purpose of this study is to investigate the relationship between the dimensions of market orientation and knowledge management functions, as well as to provide a conceptual model in this field.
Masoud Lajevardi   +3 more
doaj  

The Mediating Effects of Customer and Competitor Orientations on New Product Success

open access: yesInternational Journal of Business and Management, 2011
Market orientation, innovation, and new product success are receiving increasing attention from practitioners and scholars. Although producing new products is critical to the profitability of a firm and its long-term survival, it is a costly and risky business because of low success rates.
Stanley Kam Sing Wong, Canon Tong
openaire   +2 more sources

Adult‐Onset Subacute Sclerosing Panencephalitis Presenting With Subacute Cognitive Deficits

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT We describe the case of a 41‐year‐old man diagnosed with adult‐onset subacute sclerosing panencephalitis (SSPE). The patient presented with subacute progressive cognitive deficits and a neuropsychological profile indicating predominant frontoparietal dysfunction. MRI showed only mild parietal‐predominant cerebral atrophy.
Dennis Yeow   +4 more
wiley   +1 more source

Does Service Innovation Matter in High-Tech Industry

open access: yesJournal of Technology Management & Innovation, 2014
Service innovation has been found to be a major driver of innovation performance in service contexts. But this issue raises questions concerning the extent to which the relationship between market orientation and innovation performance holds in the high ...
Chao-Hung Wang
doaj   +1 more source

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