Results 41 to 50 of about 3,212 (267)
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Supporting Separate Compilation in a Defunctionalizing Compiler.
OpenAccess Series in Informatics, 2013 Defunctionalization is generally considered a whole-program transformation and thus incompatible with separate compilation. In this paper, we formalize a modular variant of defunctionalization which can support separate compilation. Our technique allows modules in a Haskell-like language to be separately defunctionalized and compiled, then linked ...
Georgios Fourtounis 0001 +1 more
openaire +3 more sources
ETRI Journal, 2023 Recently, embedded systems, such as mobile platforms, have multiple proces sing units that can operate in parallel, such as centralized processing units (CPUs) and neural processing units (NPUs).
Misun Yu +5 more
doaj +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Compiler Verification and Compiler Architecture
Electronic Notes in Theoretical Computer Science, 2002 AbstractWe study issues in verifying compilers for modern imperative and object-oriented languages. We take the view that it is not the compiler but the code generated by it which must be correct. It is this subtle difference that allows for reusing standard compiler architecture, construction methods and tools also in a verifying compiler.Program ...
openaire +1 more source
International Journal of Parallel Programming, 2013 This special issue presents a number of papers that discuss the design of compiler infrastructures and their use in research and education projects. Early work described in these papers was presented at the “Cetus Users and Compiler Infrastructure Workshop,” held in conjunction with the International Conference on Parallel Architectures and Compilation
Rudi Eigenmann, Samuel P. Midkiff
openaire +2 more sources
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
COCOVILA – Compiler-Compiler for Visual Languages
Electronic Notes in Theoretical Computer Science, 2005 AbstractA compiler-compiler for visual languages is presented. It has been designed as a framework for building visual programming environments that translate schemas into textual representation as well as into programs representing the deep meaning of schemas.
Pavel Grigorenko, Ando Saabas, Enn Tyugu
openaire +1 more source
FEBS Open Bio, EarlyView.ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui +10 more
wiley +1 more source