Results 51 to 60 of about 3,212 (267)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Control flow graph based code optimization using graph neural networks

open access: yesFrontiers in Robotics and AI
Selecting a good set of optimization flags requires extensive effort and expert input. While most of the prior research considers using static, spatial, or dynamic features, some of the latest research directly applied deep neural networks to source code.
Melih Peker, Ozcan Ozturk
doaj   +1 more source

Review of Research on Deep Learning Compiler [PDF]

open access: yesJisuanji kexue
With the rapid development of artificial intelligence,an increasing number of neural network models and algorithms have been proposed.Meanwhile,as Moore's Law gradually loses its effectiveness,a variety of new accelerators and computer architectures have
LIU Zhengyu, ZHANG Fan, QI Xiaofeng, GAO Yanzhao, SONG Yijing, FAN Wang
doaj   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

open access: yesFEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss   +7 more
wiley   +1 more source

A new business model in the fine arts realm based on NFT certificates and pearl codes

open access: yesDigital Business
The potential of Non-Fungible Tokens (NFTs) is highly anticipated, particularly in the realm of visual arts. However, current applications within fine arts often involve trivial processes, such as creating digital versions of artworks or replicas of ...
Eva Maria Kuehn
doaj   +1 more source

Cracking the Code: Genotype–Phenotype Correlation Models in Sarcoglycanopathies

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Sarcoglycanopathies are among the most severe limb‐girdle muscular dystrophies (LGMD), though milder presentations have been described. These diseases are primarily caused by missense variants, but the limited predictability of their effect on protein maturation, complex formation, and transport has hindered reliable genotype ...
Leonela Luce   +72 more
wiley   +1 more source

langcc: A Next-Generation Compiler Compiler

open access: yesCoRR, 2022
Traditionally, parsing has been a laborious and error-prone component of compiler development, and most parsers for full industrial programming languages are still written by hand. The author [Zim22] shows that automatic parser generation can be practical, via a number of new innovations upon the standard LR paradigm of Knuth et al.
openaire   +2 more sources

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu   +21 more
wiley   +1 more source

Compilation Techniques Specific for a Hardware Cryptography-Embedded Multimedia Mobile Processor [PDF]

open access: yesJournal of Systemics, Cybernetics and Informatics, 2007
The development of single chip VLSI processors is the key technology of ever growing pervasive computing to answer overall demands for usability, mobility, speed, security, etc.
Masa-aki FUKASE, Tomoaki Sato
doaj  

Influenza Vaccination Responses in Disabled Stroke Patients: A Single‐Center Prospective Observational Study

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to investigate the immunological response to influenza vaccination, the incidence and severity of influenza infection, and the side effects of the vaccination in patients with ischemic stroke. Methods This prospective observational study was conducted between 2023 and 2024 at Ramathibodi Hospital.
Achiraya Pakngao   +5 more
wiley   +1 more source

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