Results 141 to 150 of about 82,726 (255)

Nanographene‐Based van der Waals Organic Framework With Permanent Porosity

Angewandte Chemie, EarlyView.
Unlocking record‐breaking porosity in a supramolecular organic framework (SOF). Through the strategic design of a C3‐symmetric nanographene, a robust supramolecular framework is achieved via exclusively weak van der Waals forces. This metal‐free scaffold reaches a benchmark BET surface area of 1108 m2 g−1 –the highest to date for this class–combining ...
Arturo Oró, Rubén Turo‐Cortés, Josefina Perles, José Sánchez Costa, Jesús M. Fernández‐García, Nazario Martín   +5 more
wiley   +2 more sources

Mechanistic insight into complement C3 regulation during chronic HBV infection: effect on viral persistence and host immune response. [PDF]

J Biomed Sci
Baidya A, Dey D, Mallik S, Halder S, Khatun N, Jha R, Nandi S, Chakraborty BC, Dutta A, Banerjee S, Chowdhury A, Ahammed SKM, Datta S.   +12 more
europepmc   +1 more source

Activation of Complement (C3) in Patients with Leprosy

Leprosy Review, 1971
T, Shwe, R E, Petty
openaire   +2 more sources

Nucleophilic Gallyl Anions Enable Ga─Au Bimetallic Ammonia Activation

Angewandte Chemie, EarlyView.
Unlocking gallyl nucleophiles: Counterion control enables formation of an unsupported gallyl─gold complex. Gold coordination induces a polarity switch at gallium, enabling cooperative activation of NH3 and related N─H/O─H substrates under mild conditions.
Hellen Videa, Keelan M. Byrne, Tobias Krämer, Antonio J. Martínez‐Martínez   +3 more
wiley   +2 more sources

Targeting adipocyte ESRRA alleviates osteoarthritis via interrupting inter-organelle crosstalk of complement C3-CFD-MAC cascade. [PDF]

Bone Res
Huang T, Wang Z, Gao L, Gao J, Lu Z, Li P, Choy CH, Yuan Z, Zhong Y, Geng CA, Wang H, Yeung KWK, Li B, Pan H, Chen D, Guan M.   +15 more
europepmc   +1 more source

Coordination‐Driven Direct C─H Metalation of N‐Heterocycles With a Superbasic Co(II) Amide Co(TMP)2

Angewandte Chemie, EarlyView.
By enabling regioselectivities that are inaccessible with conventional bases, this study introduces a Co(II) amide platform for the deprotonative C─H metalation of sensitive N‐heterocycles. Subsequent interception of the resulting Co(II) intermediates with external oxidants affords a family of sterically congested, TMP‐substituted heterocycles via C─N ...
Na Jin, Manting Mu, Max García‐Melchor, Eva Hevia   +3 more
wiley   +2 more sources

Urinary complement C3 fragment levels and their clinical relevance in MPO-ANCA-associated vasculitis. [PDF]

Sci Rep
Hu Y, Shi M, Huang Q, Wan S, Zhang M, Wang Z, Huang W, Zhang S, Xiong F.   +8 more
europepmc   +1 more source

Ozone-induced cognitive deficits are mediated by the liver-brain axis: peripheral complement C3 triggers microglial synaptic phagocytosis. [PDF]

J Neuroinflammation
Wang Y, Qi H, Dong W, Chen Y, Nisubire D, Zeng Y, Li J.   +6 more
europepmc   +1 more source

Unlocking a Nitrosuccinate Lyase for Decarboxylative Enzymatic Hydronitration

Angewandte Chemie, EarlyView.
The nitrosuccinate lyase CreD catalyzes C–NO2 bond formation using nitrite in water and shows synthetic practicality with high turnover numbers up to 102,000. A combination of protein engineering and computational methods helped to reveal the mechanistic principles that underpin this unique enzymatic activity.
Matteo Aleotti, Hannah Dreisbach, Rémi Corlay, Clara Weber, Tamara Reiter, Wael Elaily, Bastian Daniel, Klaus Zangger, Pedro A. Sánchez‐Murcia, Mélanie Hall   +9 more
wiley   +2 more sources

Alternative c3 complement system

Familial hypercholesterolemia (FH) is increasingly associated with inflammation, a phenotype that persists despite treatment with lipid lowering therapies. The alternative C3 complement system (C3), as a key inflammatory mediator, seems to be involved in the atherosclerotic process; however, the relationship between C3 and lipids during plaque ...
García-Arguinzonis, Maisa||, Diaz-Riera, Elisa||, Peña, Esther||, Escate, Rafael||, Juan-Babot, Oriol||, Mata, Pedro, Badimon, Lina||, Padró, Teresa||   +7 more
openaire   +1 more source