Results 141 to 150 of about 92,727 (298)
Self-association of complement factor H in the presence and absence of metals [PDF]
, 2010 In the complement system of innate immunity, factor H (FH) is a major regulator of its activation, and is comprised of 20 short complement regulator (SCR) domains.
Nan, R.
core
Advanced Science, EarlyView.We report the fast generation of biocompatible solutions of highly 13C‐hyperpolarized (≈11%) partially‐deuterated ketoisocaproate within <6 min using spin‐lock‐induced crossing and reversible exchange with parahydrogen (SLIC‐SABRE). This enables rapid detection of branched‐chain‐amino‐acid transferase 1 (BCAT1) protein expression and investigation of ...
Stefan Petersen +18 more
wiley +1 more source
A comparative analysis of cowpox virus (CPV WT) and a deletion mutant lacking the gene encoding the inflammation modulatory protein (CPV IMP) [PDF]
, 2007 Includes bibliographical references (leaves 96-114).Cowpox virus has been found to encode the inflammation modulatory protein (IMP) (Miller, C.G., 1997), a homologue vaccinia virus complement control protein (VCP). VCP belongs to regulation of complement
Paulsen, Janis
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Advanced Science, EarlyView.ABSTRACT The dynamic interplay between bacteria and host cancer cells plays a critical role in tumor microenvironment modulation, bacterial pathogenesis, and potential oncotherapy applications. However, traditional methods often fail to capture transient or spatially restricted molecular interactions at the bacteria‐cancer cell interface.
Amin Sun +6 more
wiley +1 more source
The role of the Streptococcus pneumoniae capsule in interactions with complement and phagocytes [PDF]
, 2010 The Streptococcus pneumoniae capsule is an essential virulence factor and it is ideally situated to modulate interactions between the bacteria and host immune cells.
Hyams, C.J.
core
Advanced Science, EarlyView.An integrative single‐cell atlas across multiple metabolic diseases reveals coordinated metabolic modules and disease‐shared versus disease‐specific pathway activities. By systematically comparing scoring strategies, a robust RankAve framework is established. Coupled with network analysis and drug‐target prediction, this resource uncovers cross‐disease
Kuan Yang +10 more
wiley +1 more source
The role of complement in synaptic degeneration [PDF]
, 2012 Synapse loss is an early event of many neurodegenerative diseases including Alzheimer?s disease and Parkinson?s disease. The causes and mechanisms that underpin synapse dysfunction and degeneration are poorly understood.
Malfa, Katya
core
Advanced Science, EarlyView.Astrocytic FABP5 promotes mitochondrial stress, cGAS‐STING pathway activation, pyroptosis, and neuroinflammation in epilepsy, contributing to seizure pathology. Genetic targeting of FABP5 or pharmacological inhibition of STING alleviates epileptic phenotypes, highlighting a potential therapeutic strategy for epilepsy.
Chen Chen +10 more
wiley +1 more source
Advanced Science, EarlyView.PDGFA/PDGFRα signaling recruits CAFs to OSCC nests, and CAF‐OSCC contact drives tumor budding invasion. Mechanistically, heterotypic adhesion via E‐cadherin/integrin α2β1 activates YAP signaling in OSCC cells, inducing EMT. Concurrently, CAFs transfer mitochondria through TNTs, supplying ATP to fuel invasion.
Yufang Liu +17 more
wiley +1 more source