Results 221 to 230 of about 712,823 (260)

Complement C4B protein in schizophrenia

The World Journal of Biological Psychiatry, 2008
Partial and/or complete deficiency of the complement protein C4 is associated with autoimmune and infectious diseases. Infectious or autoimmune processes may have a role in schizophrenia. Previous reports suggest abnormalities in the complement C4B isotype in schizophrenia and other mental disorders.
K. Mayilyan, A. Dodds, A. Boyajyan, A. Soghoyan, Robert B Sim   +4 more
semanticscholar   +3 more sources

Complement C4B-null alleles in Felty's syndrome. [PDF]

Arthritis & Rheumatism, 1988
AbstractC4A and C4B allotypes were compared in 20 patients with Felty's syndrome (FS), 52 patients with rheumatoid arthritis (RA), and 55 control subjects. Nineteen of the FS patients had HLA–DR4. A C4B‐null allele was more frequent in the patients with FS (60%) than in either the RA patients (15%) or the control subjects (26%).
W. Thomson, P. Sanders, M. Davis, J. Davidson, P. Dyer, D. Grennan   +5 more
semanticscholar   +3 more sources

Investigation of complement C4B deficiency in schizophrenia.

Human Heredity, 1997
Several lines of evidence suggest that autoimmune mechanisms might contribute to the development of schizophrenia. Important factors involved in immune responses in man include the human leukocyte antigens and components of the complement system. In the present study we attempted to confirm a positive association between a homozygous deficiency in ...
R. Schroers, M. Nöthen, M. Rietschel, M. Albus, W. Maier, S. Schwab, D. Wildenauer, R. Fimmers, P. Propping, G. Dewald   +9 more
semanticscholar   +3 more sources

Complement C4A, C4B and BF haplotypes in Koreans

Tissue Antigens, 1996
Specific alleles at C4A, C4B and BF loci occur in populations and are inherited in complotypes, which are linked with particular HLA haplotypes. Considerable differences in complement allele and complotype frequencies have been observed among various ethnic groups.
K S, Park, M H, Park, T, Juji, K, Tokunaga   +3 more
openaire   +2 more sources

Decreased Plasma Concentrations of the C4B Complement Protein in Autism

Archives of Pediatrics & Adolescent Medicine, 1994
To determine complement C4 protein concentrations in the plasmas of autistic subjects and their family members.Cross-sectional study.Center for Persons with Disabilities and the Department of Biology, Utah State University, Logan.Forty-two autistic subjects (34 males [81%] and eight females [19%]), 50 of their biologic parents, 21 siblings, and 105 ...
R P, Warren, R A, Burger, D, Odell, A R, Torres, W L, Warren   +4 more
openaire   +2 more sources

Complement C4A and C4B Gene Copy Number Study in Alzheimer's Disease Patients.

Current Alzheimer Research, 2016
Background/Objectives: Increasing evidence suggests the importance of neuroinflammation in the pathogenesis of Alzheimer’s disease (AD), which is a complex neurodegenerative disorder. Complement activation occurs in the brain of patients with AD and seems to contribute to an important local inflammatory state. Increased expression of the fourth serum
M. Zorzetto, Francesca Datturi, Laura Divizia, C. Pistono, I. Campo, A. de Silvestri, M. Cuccia, G. Ricevuti   +7 more
semanticscholar   +3 more sources

Human receptor for C3b/C4b: Complement receptor type I

1987
Publisher Summary Receptor function and protein are shown to reside on cells of the myelomonocytic series, mature B lymphocytes, glomerular podocytes, a small population of T lymphocytes, follicular dendritic cells, and even in plasma. The purification scheme to be described in the chapter has made available amounts of purified CR1 sufficient for ...
W W, Wong, D T, Fearon
openaire   +2 more sources

C4b-Binding protein, a regulatory protein of complement

Immunologic Research, 1991
Despite the wealth of structural and functional information on C4BP, it is clear that several aspects of C4BP biology and regulation under normal conditions and in the acute-phase response remain unresolved. Studies to identify which interleukin and cytokines regulate C4BP expression (both α-and β-chains) are underway in our laboratory.
openaire   +2 more sources

Complement Components C4A and C4B in Human Lupus

2005
For over half a century low serum complement C4 concentrations have been recognized as a manifestation of systemic lupus erythematosus (SLE). However, the role of C4 in human SLE remains elusive. This is partly because of the unusually complex C4 genetics with frequent variations in gene number, gene size, protein isoforms, and expression levels.
Yan Yang, Erwin K. Chung, Karl Lhotta, Yee Ling Wu, Gloria C. Higgins, Robert M. Rennebohm, Lee A. Hebert, Daniel J. Birmingham, Brad H. Rovin, C. Yung Yu   +9 more
openaire   +1 more source

Diverse Functions of C4b-Binding Protein in Health and Disease.

Journal of Immunology, 2023
C4b-binding protein (C4BP) is a fluid-phase complement inhibitor that prevents uncontrolled activation of the classical and lectin complement pathways.
Lacie M. Werner, A. Criss
semanticscholar   +1 more source