Results 91 to 100 of about 2,390,880 (343)

Staphylococcus aureusClumping Factor A Binds to Complement Regulator Factor I and Increases Factor I Cleavage of C3b [PDF]

The Journal of Infectious Diseases, 2008
The human complement system plays an important role in the control of Staphylococcus aureus infection. For instance, we previously demonstrated that the central complement component deposited on the organism's surface, C3b, can be cleaved by the host complement control protein, factor I, resulting in diminished phagocytosis of S. aureus. In the present
O. John Semmes, Kenji M. Cunnion, Kenji M. Cunnion, Pamela S. Hair, Timothy J. Foster, Michael D. Ward   +5 more
openaire   +4 more sources

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source

The Role of the Complement System in the Pathogenesis of Infectious Forms of Hemolytic Uremic Syndrome

Biomolecules, 2023
Hemolytic uremic syndrome (HUS) is an acute disease and the most common cause of childhood acute renal failure. HUS is characterized by a triad of symptoms: microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury.
Piotr P. Avdonin, Maria S. Blinova, Galina A. Generalova, Khadizha M. Emirova, Pavel V. Avdonin   +4 more
doaj   +1 more source

The Factors That Influence Mother\u27s Behavior in Giving Food Complement of Breast Milk for Baby in Age 6 - 36 Month [PDF]

, 2013
Food complement of breast milk is food that contain nutrient, giving to child in age 6–36 months to complete nutrient requirement. Giving that food is precisely influenced by mother\u27s behavior who have baby.
Kristianto, Y. (Yonatan), Sulistyarini, T. (Tri)   +1 more
core   +2 more sources

Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression

Molecular Oncology, EarlyView.
Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park, Jae Won Oh, Hyewon Chung, Jung Won Kwon, Yi Rang Na, Kwang Pyo Kim, Seung Hyeok Seok   +6 more
wiley   +1 more source

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

Molecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak, Żaneta Zarębska, Marcin P. Sajek, Adriana Grabowska, Alessia Buratin, Paweł Głodowicz, Julia O. Misiorek, Konrad Kuczyński, Stefania Bortoluzzi, Marek Żywicki, Jan G. Kosiński, Agnieszka Rybak‐Wolf, Rafał Piestrzeniewicz, Anna M. Barciszewska, Katarzyna Rolle   +14 more
wiley   +1 more source

COVID-19: a trigger for severe thrombotic microangiopathy in a patient with complement gene variant

Romanian Journal of Internal Medicine, 2022
The evidence regarding thrombotic microangiopathy (TMA) related to Coronavirus Infectious Disease 2019 (COVID-19) in patients with complement gene mutations as a cause of acute kidney injury (AKI) are limited.
Pinte Larisa, Sorohan Bogdan Marian, Prohászka Zoltán, Gherghiceanu Mihaela, Băicuş Cristian   +4 more
doaj   +1 more source

Pointwise characteristic factors for Wiener Wintner double recurrence theorem [PDF]

, 2014
In this paper, we extend Bourgain's double recurrence result to the Wiener-Wintner averages. Let $(X, \mathcal{F}, \mu, T)$ be a standard ergodic system. We will show that for any $f_1, f_2 \in L^\infty(X)$, the double recurrence Wiener-Wintner average
Assani, Idris, Duncan, David, Moore, Ryo
core  

The disease-protective complement factor H allotypic variant Ile62 shows increased binding affinity for C3b and enhanced cofactor activity [PDF]

, 2009
38 p.- 7 fig.Mutations and polymorphisms in the gene encoding factor H (CFH) have been associated with atypical haemolytic uraemic syndrome, dense deposit disease and age-related macular degeneration.
de Cordoba, Santiago Rodriguez, Harris, Claire Louise, Martinez-Barricarte, Ruben, Montes, Tamara, Morgan, Bryan Paul, Tortajada, Agustin   +5 more
core   +1 more source

Function of the Factor I Modules (FIMS) of Human Complement Component C6 [PDF]

Journal of Biological Chemistry, 1999
In order to elucidate the function of complement component C6, truncated C6 molecules were expressed recombinantly. These were either deleted of the factor I modules (FIMs) (C6des-748-913) or both complement control protein (CCP) modules and FIMs (C6des-611-913).
Stuart M. Linton, N. K. Rushmere, Richard G. DiScipio   +2 more
openaire   +3 more sources