Results 101 to 110 of about 2,740,548 (363)

The Role of the Complement System in the Pathogenesis of Infectious Forms of Hemolytic Uremic Syndrome

Biomolecules, 2023
Hemolytic uremic syndrome (HUS) is an acute disease and the most common cause of childhood acute renal failure. HUS is characterized by a triad of symptoms: microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury.
Piotr P. Avdonin, Maria S. Blinova, Galina A. Generalova, Khadizha M. Emirova, Pavel V. Avdonin   +4 more
doaj   +1 more source

Function of the Factor I Modules (FIMS) of Human Complement Component C6 [PDF]

Journal of Biological Chemistry, 1999
In order to elucidate the function of complement component C6, truncated C6 molecules were expressed recombinantly. These were either deleted of the factor I modules (FIMs) (C6des-748-913) or both complement control protein (CCP) modules and FIMs (C6des-611-913).
Stuart M. Linton, N. K. Rushmere, Richard G. DiScipio   +2 more
openaire   +3 more sources

Identification of functional and diverse circulating cancer‐associated fibroblasts in metastatic castration‐naïve prostate cancer patients

Molecular Oncology, EarlyView.
Cancer‐associated fibroblasts (CAFs) promote cancer growth, invasion (metastasis), and drug resistance. Here, we identified functional and diverse circulating CAFs (cCAFs) in patients with metastatic prostate cancer (mPCa). cCAFs were found in higher numbers and were functional and diverse in mPCa patients versus healthy individuals, suggesting their ...
Richell Booijink, Leon W. M. M. Terstappen, Eshwari Dathathri, Khrystany Isebia, Jaco Kraan, John Martens, Ruchi Bansal   +6 more
wiley   +1 more source

COVID-19: a trigger for severe thrombotic microangiopathy in a patient with complement gene variant

Romanian Journal of Internal Medicine, 2022
The evidence regarding thrombotic microangiopathy (TMA) related to Coronavirus Infectious Disease 2019 (COVID-19) in patients with complement gene mutations as a cause of acute kidney injury (AKI) are limited.
Pinte Larisa, Sorohan Bogdan Marian, Prohászka Zoltán, Gherghiceanu Mihaela, Băicuş Cristian   +4 more
doaj   +1 more source

Simulations in Rank-Based Büchi Automata Complementation (Technical Report) [PDF]

arXiv, 2019
Complementation of B\"uchi automata is an essential technique used in some approaches for termination analysis of programs. The long search for an optimal complementation construction climaxed with the work of Schewe, who proposed a worst-case optimal rank-based procedure that generates complements of a size matching the theoretical lower bound of $(0 ...
arxiv  

Cell‐free and extracellular vesicle microRNAs with clinical utility for solid tumors

Molecular Oncology, EarlyView.
Cell‐free microRNAs (cfmiRs) are small‐RNA circulating molecules detectable in almost all body biofluids. Innovative technologies have improved the application of cfmiRs to oncology, with a focus on clinical needs for different solid tumors, but with emphasis on diagnosis, prognosis, cancer recurrence, as well as treatment monitoring.
Yoshinori Hayashi, Janelle‐Cheri Millen, Romela Irene Ramos, Jennifer A. Linehan, Timothy G. Wilson, Dave S. B. Hoon, Matias A. Bustos   +6 more
wiley   +1 more source

Human Complement Regulators C4b-Binding Protein and C1 Esterase Inhibitor Interact with a Novel Outer Surface Protein of Borrelia recurrentis [PDF]

, 2010
The spirochete Borrelia recurrentis is the causal agent of louse-borne relapsing fever and is transmitted to humans by the infected body louse Pediculus humanus. We have recently demonstrated that the B.
A Thern, AM Blom, B Dahlback, B Dahlback, C Caliezi, C Larsson, C Larsson, Christiane Brenner, D Hulinska, D Raoult, E Johnsson, E Rossmann, G Ben-Menachem, G Stubs, I Gigli, IV Koroleva, J Scharfstein, JC Scott, JD Lambris, JV McDowell, K Berggard, K Hartmann, KM Hovis, KM Hovis, KM Hovis, KO Sundnes, L Houhamdi, M Lescot, M Vancova, Markus M. Simon, MD Kramer, Melanie Schott, MJ Colombo, MK Pangburn, MU Norman, NV Prasadarao, P Kraiczy, P Kraiczy, PF Zipfel, PM Southern, R Schwalbe, R Wallich, R Wallich, RA Schwalbe, Reinhard Wallich, S Alberti, S Grosskinsky, S Kuhn, S Ram, S Ram, Sally J. Cutler, Sheila Lukehart, SJ Cutler, SJ Cutler, Sonja Grosskinsky, SS Bartra, T Fujita, T Meri, T Meri, T Nordstrom, UE Schaible, V Kirjavainen, WR Zuckert, WR Zuckert, YJ Ma   +64 more
core   +3 more sources

On operators with bounded approximation property [PDF]

arXiv, 2013
It is known that any separable Banach space with BAP is a complemented subspace of a Banach space with a basis. We show that every operator with bounded approximation property, acting from a separable Banach space, can be factored through a Banach space with a basis.
arxiv  

Universal spectral correlations in interacting chaotic few-body quantum systems [PDF]

arXiv, 2023
The emergence of random matrix spectral correlations in interacting quantum systems is a defining feature of quantum chaos. We study such correlations in terms of the spectral form factor and its moments in interacting chaotic few- and many-body systems, modeled by suitable random-matrix ensembles.
arxiv  

Cellular liquid biopsy provides unique chances for disease monitoring, preclinical model generation and therapy adjustment in rare salivary gland cancer patients

Molecular Oncology, EarlyView.
We quantified and cultured circulating tumor cells (CTCs) of 62 patients with various cancer types and generated CTC‐derived tumoroid models from two salivary gland cancer patients. Cellular liquid biopsy‐derived information enabled molecular genetic assessment of systemic disease heterogeneity and functional testing for therapy selection in both ...
Nataša Stojanović Gužvić, Florian Lüke, Steffi Treitschke, Andrea Coluccio, Martin Hoffmann, Giancarlo Feliciello, Adithi Ravikumar Varadarajan, Xin Lu, Kathrin Weidele, Catherine Botteron, Silvia Materna–Reichelt, Felix Keil, Katja Evert, Florian Weber, Thomas Schamberger, Michael Althammer, Jirka Grosse, Dirk Hellwig, Christian Schulz, Stephan Seitz, Peter Ugocsai, Anke Schlenska‐Lange, Roman Mayr, Ulrich Kaiser, Wolfgang Dietmaier, Bernhard Polzer, Jens Warfsmann, Kamran Honarnejad, Tobias Pukrop, Daniel Heudobler, Christoph A. Klein, Christian Werno   +31 more
wiley   +1 more source