Results 111 to 120 of about 2,390,880 (343)

Thrombotic microangiopathies: thrombotic thrombocytopenic purpura / hemolytic uremic syndrome [PDF]

, 2010
Thrombotic microangiopathies (TMAs) are pathological conditions characterized by generalized microvascular occlusion by platelet thrombi, thrombocytopenia, and microangiopathic hemolytic anemia.
Mastroianni Kirsztajn, Gianna, Polito, Maria Goretti   +1 more
core   +2 more sources

Time, the final frontier

Molecular Oncology, EarlyView.
This article advocates integrating temporal dynamics into cancer research. Rather than relying on static snapshots, researchers should increasingly consider adopting dynamic methods—such as live imaging, temporal omics, and liquid biopsies—to track how tumors evolve over time.
Gautier Follain, Michal Dibus, Omkar Joshi, Guillaume Jacquemet   +3 more
wiley   +1 more source

Impact of Strongyloides stercoralis infection on complement activation in Type 2 diabetes mellitus: Insights from a clinical and anthelmintic intervention study.

PLoS Neglected Tropical Diseases
BackgroundNumerous studies indicate a potential protective role of helminths in diabetes mellitus (DM) progression. The complement system, vital for host defense, plays a crucial role in tissue homeostasis and immune surveillance. Dysregulated complement
Anuradha Rajamanickam, Bindu Dasan, Saravanan Munisankar, Sujatha Nott, Pradeep A Menon, Fayaz Ahamed Shaik, Ponnuraja Chinnaiyan, Thomas B Nutman, Subash Babu   +8 more
doaj   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

Atypical hemolytic uremic syndrome

Orphanet Journal of Rare Diseases, 2011
Hemolytic uremic syndrome (HUS) is defined by the triad of mechanical hemolytic anemia, thrombocytopenia and renal impairment. Atypical HUS (aHUS) defines non Shiga-toxin-HUS and even if some authors include secondary aHUS due to Streptococcus pneumoniae
Frémeaux-Bacchi Véronique, Loirat Chantal   +1 more
doaj   +1 more source

aHUS caused by complement dysregulation: new therapies on the horizon [PDF]

, 2011
Atypical hemolytic uremic syndrome (aHUS) is a heterogeneous disease that is caused by defective complement regulation in over 50% of cases. Mutations have been identified in genes encoding both complement regulators [complement factor H (CFH ...
A Dmytrijuk, A Gerber, A Richards, A Richards, A Zurowska, AL Lapeyraque, AL Sellier-Leclerc, AM Waters, Aoife M. Waters, BA Vogt, BH Lee, BS Kaplan, BS Kaplan, C Abarrategui-Garrido, C Licht, C Loirat, C Loirat, C Parker, C Skerka, CA Fijen, CA Ogden, Christoph Licht, CJ Mache, CJ Parker, CM Taylor, D Barz, D Karpman, D Kavanagh, D Kavanagh, D Kavanagh, D Landau, D Perez-Caballero, DF O'Shaughnessy, E Bresin, E Goicoechea de Jorge, E Wagner, F Bienaime, F Vaziri-Sani, G Ariceta, G Filler, G Remuzzi, G Remuzzi, G Remuzzi, H Baeyer von, H Jalanko, H Kleanthous, HE Nielsen, HY Cho, I Moore, IM Ponce-Castro, J Caprioli, J Caprioli, J Caprioli, J Esparza-Gordillo, J Esparza-Gordillo, J Geelen, J Nurnberger, JC Davin, JC Davin, JD Stratton, JM Cruzado, JM Saland, JM Saland, JM Weiler, JP Venables, K Lhotta, K Whaley, L Couzi, M Brai, M Delvaeye, M Jozsi, M Jozsi, M Levy, M Noris, M Noris, M Noris, M Ohali, M Quintrec Le, MA Dragon-Durey, MA Dragon-Durey, MA Karmali, MA Rizvi, MC Pickering, MK Pangburn, MR Chan, MT Geraghty, N Rougier, O Boyer, P Hillmen, P Warwicker, PF Zipfel, PF Zipfel, PF Zipfel, R Medzhitov, RA Gruppo, RA Thompson, RE Saunders, RL Donne, RP Rother, S De, S Heinen, S Nathanson, S Nathanson, S Strobel, SC Nilsson, SC Nilsson, SH Rooijakkers, SK Sethi, SL Allford, T Kwon, T Manuelian, T Nishimura, V Chatelet, V Fremeaux-Bacchi, V Fremeaux-Bacchi, V Fremeaux-Bacchi, V Fremeaux-Bacchi, V Pichette, WR Bell, Z Bircan   +119 more
core   +2 more sources

Biological and technical complexities in analyzing extracellular vesicle immune interactions in B‐cell malignancies

FEBS Letters, EarlyView.
Daniel Bachurski, Michael Hallek
wiley   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Survival of Borrelia burgdorferi Strain B31 in Human Serum Is Not Dependent on C4BP Binding to the Bacterial Surface

Pathogens
Lyme disease is a vector-borne illness caused by spirochetes belonging to the Borrelia burgdorferi species group. These bacteria employ several mechanisms to survive within the vertebrate host, including evasion of the complement system.
Tobias Jakobsson, Pär Comstedt, Sven Bergström, Johan Normark   +3 more
doaj   +1 more source

The nature of child-adult interaction : from turn-taking to understanding pointing and use of pointing gestures [PDF]

, 2014
Analyses of interactions between an adult and a one-year-old child are often connected with studying early communicative competences, e.g. the child’s participation in turn-taking sequences, in joint attention, and use of pointing gestures.
Białecka-Pikul, Marta, Białek, Arkadiusz, Stępień-Nycz, Małgorzata   +2 more
core   +1 more source