Results 131 to 140 of about 2,390,880 (343)

High Complement Factor I Activity in the Plasma of Children with Autism Spectrum Disorders

Autism Research and Treatment, 2011
Autism spectrum disorders (ASDs) are neurodevelopmental and behavioural syndromes affecting social orientation, behaviour, and communication that can be classified as developmental disorders. ASD is also associated with immune system abnormality.
N. Momeni, L. Brudin, F. Behnia, Berit M Nordström, Ali Yosefi-Oudarji, B. Sivberg, M. Joghataei, B. Persson   +7 more
semanticscholar   +1 more source

Therapeutic applications of a novel humanized monoclonal antibody targeting chemokine receptor CCR9 in pancreatic cancer

Molecular Oncology, EarlyView.
C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald, Anna M. Reagan, Charles J. Bailey, Mei Gao, Muqiang Gao, Angelica L. Solomon, Michael J. Cavnar, Prakash K. Pandalai, Mautin T. Barry‐Hundeyin, Megan M. Harper, Justin A. Rueckert, Ángela Turrero, Araceli Tobio, Anxo Vidal, Daniel Roca‐Lema, Elia Álvarez‐Coiradas, Pablo Garrido, Laureano Simón, Joseph Kim   +18 more
wiley   +1 more source

Genetics and complement in atypical HUS [PDF]

Central to the pathogenesis of atypical hemolytic uremic syndrome (aHUS) is over-activation of the alternative pathway of complement. Following the initial discovery of mutations in the complement regulatory protein, factor H, mutations have been ...
A Fogo, A Richards, A Richards, A Richards, A Richards, A Richards, A Tortajada, AI Okemefuna, AL Sellier-Leclerc, AL Stahl, AL Stahl, AM Blom, C Abarrategui-Garrido, C Abarrategui-Garrido, C Loirat, CJ Fang, CQ Schmidt, D Kavanagh, D Kavanagh, D Kavanagh, D Kavanagh, D Kavanagh, D Kavanagh, D Perez-Caballero, D Westra, David Kavanagh, DE Jenne, E Bresin, E Goicoechea de Jorge, E Goicoechea de Jorge, F Bienaime, F Vaziri-Sani, G Ariceta, G Monteferrante, GA Hegasy, GD Ross, H Weiler, HG Hocking, HP Neumann, I Moore, J Caprioli, J Esparza-Gordillo, J Esparza-Gordillo, J Scharfstein, J Tschopp, JP Venables, K Lhotta, K Whaley, LT Roumenina, M Delvaeye, M Jozsi, M Jozsi, M Jozsi, M Noris, M Noris, M Sullivan, MA Dragon-Durey, MA Dragon-Durey, MC Pickering, MC Pickering, ME Medof, MJ Lehtinen, MK Liszewski, MK Pangburn, MK Pangburn, P Sanchez-Corral, P Sanchez-Corral, P Warwicker, PF Paula de, PF Zipfel, PI Tarr, R Martinez-Barricarte, R Martinez-Barricarte, R Nan, S Heinen, S Heinen, S Nagasawa, S Rodriguez de Cordoba, S Rodriguez de Cordoba, S Shiraishi, SC Nilsson, SC Nilsson, T Fujita, T Manuelian, Tim Goodship, TS Jokiranta, V Fremeaux-Bacchi, V Fremeaux-Bacchi, V Fremeaux-Bacchi, V Fremeaux-Bacchi, VP Ferreira   +90 more
core   +2 more sources

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Effect of anti-C5 antibody on recuperation from ischemia/reperfusion-induced acute kidney injury

Renal Failure, 2019
Aim: The complement system is activated in acute kidney injury (AKI). Anti-C5 antibody targets the common terminal portion of the complement cascade that generate the terminal complex C5b-9 and has a renal-protective effect in paroxysmal nocturnal ...
Shani Zilberman-Itskovich, Ramzia Abu-Hamad, Moshe Stark, Shai Efrati   +3 more
doaj   +1 more source

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

Molecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach, Nilesh Chatterjee, Kellie Spahr, Gilberto Serrano de Almeida, Anabel Varela‐Carver, Taimur T. Shah, Mathias Winkler, Hashim U. Ahmed, Charlotte L. Bevan   +8 more
wiley   +1 more source

The interaction of C3b bound to pneumococci with factor H (beta 1H globulin), factor I (C3b/C4b inactivator), and properdin factor B of the human complement system. [PDF]

, 1983
E.J. Brown, Keith A. Joiner, T A Gaither, Carl H. Hammer, Martin Frank   +4 more
openalex   +1 more source

A DIA‐MS‐based proteomics approach to find potential serum prognostic biomarkers in glioblastoma patients

Molecular Oncology, EarlyView.
A DIA‐MS‐based proteomics analysis of serum samples from GB patients and healthy controls showed that high levels of IL1R2 and low levels of CRTAC1 and HRG in serum are associated with poor survival outcomes for GB patients. These circulating proteins could serve as biomarkers for the prediction of outcome in patients with GB.
Anne Clavreul, François Guillonneau, Odile Blanchet, Hamza Lasla, Audrey Rousseau, Catherine Guette, Alice Boissard, Cécile Henry, Morgan Dhondt, Pascal Jézéquel, Philippe Menei, Jean‐Michel Lemée   +11 more
wiley   +1 more source

De Novo Atypical Haemolytic Uremic Syndrome after Kidney Transplantation

Case Reports in Nephrology, 2018
De novo thrombotic microangiopathy (TMA) can occur after kidney transplantation. An abnormality of the alternative pathway of complement must be suspected and searched for, even in presence of a secondary cause. We report the case of a 23-year-old female
Arnaud Devresse, Martine de Meyer, Selda Aydin, Karin Dahan, Nada Kanaan   +4 more
doaj   +1 more source

Factors Affecting Complement Activation by Staphylococcus aureus Cell Walls, Their Components, and Mutants Altered in Teichoic Acid [PDF]

, 1981
Brian J. Wilkinson, Youngki Kim, Phillip K. Peterson   +2 more
openalex   +1 more source