Results 151 to 160 of about 2,390,880 (343)

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source

Complement Factor I Gene Variant as a Treatable Cause of Recurrent Aseptic Neutrophilic Meningitis: A Case Report. [PDF]

Neurol Neuroimmunol Neuroinflamm, 2023
Rolfes M, Harroud A, Zorn KC, Tubati A, Omura C, Kurtz K, Matloubian M, Berger A, Chiu CY, Wilson MR, Ramachandran PS.   +10 more
europepmc   +1 more source

The YeastCandida albicansBinds Complement Regulators Factor H and FHL-1 [PDF]

, 2002
Taru Meri, Andrea Hartmann, D. Lenk, Raimund Eck, Reinhard Würzner, Jens Hellwage, Seppo Meri, Peter F. Zipfel   +7 more
openalex   +1 more source

Possible role of human ribonuclease dicer in the regulation of R loops

FEBS Open Bio, EarlyView.
R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik, Paulina Krzeminska, Anna Kurzynska‐Kokorniak   +2 more
wiley   +1 more source

The specific contributions of factor H and factor I in controlling fluid phase activation of the alternative complement pathway

Scientific Reports
The immediate defense provided by the alternative complement pathway (AP) is under constant control by fluid phase regulators, factor H (FH) and factor I (FI), to prevent nonessential activation.
Nancy A. Turner, Joel L. Moake
doaj   +1 more source

Rapid genome sequencing identifies novel variants in complement factor I. [PDF]

Cold Spring Harb Mol Case Stud, 2022
Rodriguez KM, Vaught J, Dilley M, Ellsworth K, Heinen A, Abud EM, Zhang Y, Smith RJH, Sheets R, Geng B, Hoffman HM, Worthen HM, Dimmock D, Coufal NG.   +13 more
europepmc   +1 more source

Long non‐coding RNAs as therapeutic targets in head and neck squamous cell carcinoma and clinical application

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran, Ruchi A. Patel, Amogh Chariyamane, Ratna B. Ray   +3 more
wiley   +1 more source

Rare Dysfunctional Complement Factor I Genetic Variants and Progression to Advanced Age-Related Macular Degeneration. [PDF]

Ophthalmol Sci, 2023
Seddon JM, Rosner B, De D, Huan T, Java A, Atkinson J.   +5 more
europepmc   +1 more source

Ontogeny of Complement Regulatory Proteins – Concentrations of Factor H, Factor I, C4b‐Binding Protein, Properdin and Vitronectin in Healthy Children of Different Ages and in Adults [PDF]

, 2003
P. Ferreira de Paula, J. E. Barbosa, Pérsio Roxo Júnior, Virgínia Paes Leme Ferriani, M R D O Latorre, Víctor Nudelman, Lourdes Isaac   +6 more
openalex   +1 more source

Neurotoxic amyloid β‐peptide and tau produce cytokine‐like effects on PMCA in glioblastoma cell lines, enhancing its activity and isoforms expression

FEBS Open Bio, EarlyView.
Two biomarkers of Alzheimer's disease, amyloid β‐peptide (Aβ) and tau, induce the transformation of U‐251 and other glioblastoma cell lines into neurotoxic A1‐like reactive astrocytes. This transformation is produced by cytokines and is followed by upregulation of PMCA activity and isoform expression, and is closely associated with inflammation, as ...
María Berrocal, Alberto Alvarez‐Barrientos, Ana M. Mata   +2 more
wiley   +1 more source