Rapid genome sequencing identifies novel variants in complement factor I. [PDF]
Cold Spring Harb Mol Case Stud, 2022 Complement factor I deficiency (CFID; OMIM #610984) is a rare immunodeficiency caused by deficiencies in the serine protease complement factor I (CFI). CFID is characterized by predisposition to severe pneumococcal infection, often in infancy.
Rodriguez KM +13 more
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Complement Dysregulation in Obese Versus Nonobese Polycystic Ovary Syndrome Patients
Cells, 2023 Introduction: Upregulation of complement system factors are reported to be increased in polycystic ovary syndrome (PCOS) and may be due to obesity and insulin resistance rather than inherently due to PCOS.
Alexandra E. Butler +3 more
doaj +1 more source
Complete recovery after complement factor I deficiency associated fulminant acute hemorrhagic leukoencephalitis: a case report [PDF]
Front ImmunolSzumutku F +12 more
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Eukaryotic translation elongation factor 1A (eEF1A) domain I from S. cerevisiae is required but not sufficient for inter-species complementation [PDF]
, 2012 Ethanolamine phosphoglycerol (EPG) is a protein modification attached exclusively to eukaryotic elongation factor 1A (eEF1A). In mammals and plants, EPG is linked to conserved glutamate residues located in eEF1A domains II and III, whereas in the ...
Eva Greganova +5 more
core +9 more sources
Frontiers in Immunology, 2022 Multidrug-resistant Acinetobacter baumannii is known to be one of the leading pathogens that cause severe nosocomial infections. To overcome eradication by the innate immune system during infection, A.
Julia I. Ries +6 more
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Complement‐activating ability of leucocytes from patients with‘qc complement factor I deficiency [PDF]
Immunology, 1997 Previous studies from this laboratory have shown that normal peripheral blood B cells are capable of activating complement via the alternative pathway (AP), that the activation is associated with complement receptor type 2 (CR2) expression, and that erythrocytes at normal blood levels partially inhibit the activation.
Hanne Vibeke Marquart +2 more
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Complement factor I in health and disease [PDF]
Molecular Immunology, 2011 Factor I (FI) is a crucial inhibitor controlling all complement pathways due to its ability to degrade activated complement proteins C3b and C4b in the presence of cofactors such as factor H, C4b-binding protein, complement receptor 1 or CD46.
Sara C. Nilsson +4 more
openalex +6 more sources
Genetic Risk in Families with Age-Related Macular Degeneration
Ophthalmology Science, 2021 Purpose: To determine the contribution of common and rare genetic risk variants in families with age-related macular degeneration (AMD). Design: Case-control study.
Anita de Breuk, MD +6 more
doaj +1 more source
Genetic, molecular and functional analyses of complement factor I deficiency [PDF]
European Journal of Immunology, 2008 AbstractComplete deficiency of complement inhibitor factor I (FI) results in secondary complement deficiency due to uncontrolled spontaneous alternative pathway activation leading to susceptibility to infections. Current genetic examination of two patients with near complete FI deficiency and three patients with no detectable serum FI and also close ...
Sara C. Nilsson +11 more
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Profiling Complement System Components in Primary CNS Vasculitis
Cells, 2021 Complement activation has been implicated in the pathogenesis of many vasculitic syndromes such as anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides.
Milani Deb-Chatterji +6 more
doaj +1 more source