Results 21 to 30 of about 1,866,008 (218)

Complement Dysregulation in Obese Versus Nonobese Polycystic Ovary Syndrome Patients

Cells, 2023
Introduction: Upregulation of complement system factors are reported to be increased in polycystic ovary syndrome (PCOS) and may be due to obesity and insulin resistance rather than inherently due to PCOS.
Alexandra E. Butler, Abu Saleh Md Moin, Thozhukat Sathyapalan, Stephen L. Atkin   +3 more
doaj   +1 more source

CipA mediates complement resistance of Acinetobacter baumannii by formation of a factor I-dependent quadripartite assemblage

Frontiers in Immunology, 2022
Multidrug-resistant Acinetobacter baumannii is known to be one of the leading pathogens that cause severe nosocomial infections. To overcome eradication by the innate immune system during infection, A.
Julia I. Ries, Marie Heß, Noura Nouri, Thomas A. Wichelhaus, Stephan Göttig, Franco H. Falcone, Peter Kraiczy   +6 more
doaj   +1 more source

Complement factor I upregulates expression of matrix metalloproteinase‐13 and ‐2 and promotes invasion of cutaneous squamous carcinoma cells

Experimental Dermatology, 2021
The incidence of cutaneous squamous cell carcinoma (cSCC) is increasing globally. Here, we have studied the functional role of complement factor I (CFI) in the progression of cSCC.
Pegah Rahmati Nezhad, P. Riihilä, M. Piipponen, M. Kallajoki, S. Meri, L. Nissinen, V. Kähäri   +6 more
semanticscholar   +1 more source

Complement Factor I deficiency: A novel homozygous gene mutation

SAGE Open Medical Case Reports, 2022
Complement Factor I deficiency is a very rare autosomal recessive disease, with only 38 cases reported in the literature. It is caused by a homozygous mutation in the CFI gene (complement Factor I), which encodes for the Factor I protein, an important ...
Wafaa Bouzroud, Amal Tazzite, Ibenbrahim yousra, Bouchaïb Gazzaz, Hind Dehbi   +4 more
doaj   +1 more source

Profiling Complement System Components in Primary CNS Vasculitis

Cells, 2021
Complement activation has been implicated in the pathogenesis of many vasculitic syndromes such as anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides.
Milani Deb-Chatterji, Christian W. Keller, Simon Koch, Heinz Wiendl, Christian Gerloff, Tim Magnus, Jan D. Lünemann   +6 more
doaj   +1 more source

C3 glomerulonephritis and thrombotic microangiopathy of renal allograft after pulmonary infection in a male with concomitant two complement factor I gene variations: a case report. [PDF]

BMC Nephrol, 2018
Background It has been suggested that C3 glomerulonephritis (C3GN) and atypical hemolytic-uremic syndrome (a stereotypical phenotype of thrombotic microangiopathy), two rare entities caused by complement alternative pathway dysregulation share ...
Wen J, Wang W, Xu F, Sun J, Chen J, Ni X.   +5 more
europepmc   +2 more sources

Synovial Complement Factors in Patients with Periprosthetic Joint Infection after Undergoing Revision Arthroplasty of the Hip or Knee Joint

Diagnostics, 2021
The role and diagnostic value of the synovial complement system in patients with low-grade periprosthetic joint infection (PJI) are unclear. We sought to evaluate, for the first time, the usefulness of synovial complement factors in these patients by ...
Frank Sebastian Fröschen, Sophia Schell, Matthias Dominik Wimmer, Gunnar Thorben Rembert Hischebeth, Hendrik Kohlhof, Sascha Gravius, Thomas Martin Randau   +6 more
doaj   +1 more source

Complement, but Not Platelets, Plays a Pivotal Role in the Outcome of Mucormycosis In Vivo

Journal of Fungi, 2023
Background: Mucormycetes, a heterogeneous group of fungi, induce a life-threatening disease called mucormycosis. Immune deficiencies represent a major risk factor; hence, we wanted to illuminate the role of complement and platelets in the defense against
Verena Harpf, Günter Rambach, Nadia Parth, Magdalena Neurauter, Verena Fleischer, Michaela Lackner, Cornelia Lass-Flörl, Reinhard Würzner, Cornelia Speth   +8 more
doaj   +1 more source

Characteristics and management of thrombotic microangiopathy in kidney transplantation

Korean Journal of Transplantation, 2023
Thrombotic microangiopathy is not a rare complication of kidney transplantation and is characterized by microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury with extensive thrombosis of the arterioles and capillaries.
Wonyong Cho, Sang-Kyung Jo, Cheol Woong Jung, Myung-Gyu Kim   +3 more
doaj   +1 more source

Deletion of complement factor H-related genes CFHR1 and CFHR3 is associated with atypical hemolytic uremic syndrome. [PDF]

PLoS Genetics, 2007
Atypical hemolytic uremic syndrome (aHUS) is associated with defective complement regulation. Disease-associated mutations have been described in the genes encoding the complement regulators complement factor H, membrane cofactor protein, factor B, and ...
Peter F Zipfel, Matthew Edey, Stefan Heinen, Mihály Józsi, Heiko Richter, Joachim Misselwitz, Bernd Hoppe, Danny Routledge, Lisa Strain, Anne E Hughes, Judith A Goodship, Christoph Licht, Timothy H J Goodship, Christine Skerka   +13 more
doaj   +1 more source