Results 21 to 30 of about 2,390,880 (343)

Serum complement factor I is associated with disease activity of systemic lupus erythematosus. [PDF]

Oncotarget, 2018
Although aberrant complement activation is involved in the pathogenesis of systemic lupus erythematosus (SLE), the role of complement regulatory proteins in disease activity of SLE remains limited.
Tseng MH, Lin SH, Wu CY, Chien HP, Yang HY, Chen YC, Chou YC, Huang JL.   +7 more
europepmc   +2 more sources

Deletion of complement factor H-related genes CFHR1 and CFHR3 is associated with atypical hemolytic uremic syndrome. [PDF]

PLoS Genetics, 2007
Atypical hemolytic uremic syndrome (aHUS) is associated with defective complement regulation. Disease-associated mutations have been described in the genes encoding the complement regulators complement factor H, membrane cofactor protein, factor B, and ...
Peter F Zipfel, Matthew Edey, Stefan Heinen, Mihály Józsi, Heiko Richter, Joachim Misselwitz, Bernd Hoppe, Danny Routledge, Lisa Strain, Anne E Hughes, Judith A Goodship, Christoph Licht, Timothy H J Goodship, Christine Skerka   +13 more
doaj   +5 more sources

A surface lipoprotein on Pasteurella multocida binds complement factor I to promote immune evasion. [PDF]

PLoS Pathogens
Pasteurella multocida is the leading cause of wound infections in humans following animals' bites or scratches. This bacterium is also commonly found in the respiratory tract of many mammals and can cause serious diseases resulting in the rapid death of ...
Quynh Huong Nguyen, Chun Heng Royce Lai, Michael J Norris, Dixon Ng, Megha Shah, Christine Chieh-Lin Lai, David E Isenman, Trevor F Moraes   +7 more
doaj   +2 more sources

C3 glomerulonephritis and thrombotic microangiopathy of renal allograft after pulmonary infection in a male with concomitant two complement factor I gene variations: a case report [PDF]

BMC Nephrology, 2018
Background It has been suggested that C3 glomerulonephritis (C3GN) and atypical hemolytic-uremic syndrome (a stereotypical phenotype of thrombotic microangiopathy), two rare entities caused by complement alternative pathway dysregulation share ...
Jiqiu Wen, Wei Wang, Feng Xu, Jun Sun, Jinsong Chen, Xuefeng Ni   +5 more
doaj   +2 more sources

Atypical hemolytic-uremic syndrome due to complement factor I mutation. [PDF]

World J Nephrol, 2017
Atypical hemolytic-uremic syndrome (aHUS) is a rare disease of complement dysregulation leading to thrombotic microangiopathy (TMA). Renal involvement and progression to end-stage renal disease are common in untreated patients. We report a 52-year-old female patient who presented with severe acute kidney injury, microangiopathic hemolytic anemia, and ...
Almalki AH, Sadagah LF, Qureshi M, Maghrabi H, Algain A, Alsaeed A.   +5 more
europepmc   +5 more sources

Plasma Levels of Complement Factor I and C4b Peptides Are Associated with HIV Suppression. [PDF]

ACS Infect Dis, 2017
Individuals who exhibit long-term HIV suppression and CD4 T-cell preservation without antiretroviral therapy are of great interest for HIV research. There is currently no robust method for rapid identification of these “HIV controller” subjects; however,
Wu B, Ouyang Z, Lyon CJ, Zhang W, Clift T, Bone CR, Li B, Zhao Z, Kimata JT, Yu XG, Hu Y.   +10 more
europepmc   +2 more sources

The Staphylococcus aureus protein Sbi acts as a complement inhibitor and forms a tripartite complex with host complement Factor H and C3b. [PDF]

PLoS Pathogens, 2008
The Gram-positive bacterium Staphylococcus aureus, similar to other pathogens, binds human complement regulators Factor H and Factor H related protein 1 (FHR-1) from human serum.
Katrin Haupt, Michael Reuter, Jean van den Elsen, Julia Burman, Steffi Hälbich, Julia Richter, Christine Skerka, Peter F Zipfel   +7 more
doaj   +6 more sources

The molecular basis of hereditary complement factor I deficiency. [PDF]

Journal of Clinical Investigation, 1996
The molecular basis of hereditary complement factor I deficiency is described in two pedigrees. In one pedigree, there were two factor I-deficient siblings, one of whom was asymptomatic and the other suffered from recurrent pyogenic infections.
T. Vyse, A. Webster, M. Walport, J. Clin, T. Vyse, B. J. Morley, I. Bartok, E. Theodoridis, K. Davies, A. Webster   +9 more
semanticscholar   +4 more sources

Complete recovery after complement factor I deficiency associated fulminant acute hemorrhagic leukoencephalitis: a case report [PDF]

Frontiers in Immunology
IntroductionAcute hemorrhagic leukoencephalitis (AHLE) is a rare, fulminant neuroinflammatory disease with high mortality rate. It most often occurs after infections; however, the exact etiology of the disease remains unclear.
Fanni Szumutku, Léna Szabó, Zoltán Liptai, Edit Varga, Tímea Seszták, Péter Barsi, Ádám Goschler, Gábor Szarvas, Klára Horváth, Simon Péter Nagy, Zoltán Prohászka, Ágnes Szilágyi, Sarolta Dobner   +12 more
doaj   +2 more sources

Complement factor I: Regulatory nexus, driver of immunopathology, and therapeutic.

Immunobiology, 2023
Complement factor I (FI) is the nexus for classical, lectin and alternative pathway complement regulation. FI is an 88 kDa plasma protein that circulates in an inactive configuration until it forms a trimolecular complex with its cofactor and substrate whereupon a structural reorganization allows the catalytic triad to cleave its substrates, C3b and ...
T. Hallam, S. Sharp, A. Andreadi, D. Kavanagh   +3 more
semanticscholar   +4 more sources