Results 31 to 40 of about 2,390,880 (343)

Complement factor I deficiency: a not so rare immune defect. Characterization of new mutations and the first large gene deletion

Orphanet Journal of Rare Diseases, 2012
Background Complement Factor I (CFI) is a serine protease with an important role in complement alternative pathway regulation. Complete factor I deficiency is strongly associated with severe infections. Approximately 30 families with this deficiency have
Alba-Domínguez María, López-Lera Alberto, Garrido Sofía, Nozal Pilar, González-Granado Ignacio, Melero Josefa, Soler-Palacín Pere, Cámara Carmen, López-Trascasa Margarita   +8 more
doaj   +2 more sources

Isolation and characterization of factor I of the bovine complement system [PDF]

American Journal of Veterinary Research, 2003
Abstract Objective—To isolate and characterize factor I of the bovine complement system. Sample Population—Serum obtained from the blood of beef cattle. Procedures—Serum samples were fractionated to yield factor I by means of sequential precipitation, ionexchange, and gel-filtration chromatography.
Marilyn Menger, W.P. Aston
openalex   +4 more sources

Elastase of Pseudomonas aeruginosa : Inactivation of Complement Components and Complement-Derived Chemotactic and Phagocytic Factors [PDF]

Infection and Immunity, 1974
A purified elastase from Pseudomonas aeruginosa was highly destructive for fluid-phase and cell-bound C1 and C3 and fluid-phase C5, C8, and C9. Inactivation of C4, C2, C6, and C7 by the enzyme varied from 0 to 67%. Low concentrations of elastase generated, then inactivated, a chemotactic factor from human C5 but not
Duane R. Schultz, Kent D. Miller
openalex   +4 more sources

Complement factor I deficiency associated with recurrent meningitis coinciding with menstruation. [PDF]

Archives of Neurology, 2001
BACKGROUND Complement (C) factor I deficiency is a rare immunodeficiency state frequently associated with recurrent pyogenic infections in early infancy.
C. González-Rubio, Antonio Ferreira-Cerdán, Isabel M. Ponce, J. Arpa, G. Fontán, M. López-Trascasa   +5 more
semanticscholar   +3 more sources

Evaluating a Causal Relationship between Complement Factor I Protein Level and Advanced Age-Related Macular Degeneration Using Mendelian Randomization. [PDF]

Ophthalmol Sci, 2022
Jones AV, MacGregor S, Han X, Francis J, Harris C, SCOPE Study group, Kavanagh D, Lotery A, Waheed N.   +8 more
europepmc   +3 more sources

Complement factor I promotes progression of cutaneous squamous cell carcinoma. [PDF]

Journal of Investigative Dermatology, 2015
The incidence of cutaneous squamous cell carcinoma (cSCC) is rising worldwide. We have examined the role of complement components in the progression of cSCC. Analysis of cSCC cell lines (n=8) and normal human epidermal keratinocytes (n=11) with whole transcriptome profiling (SOLiD), quantitative real-time reverse transcriptase-PCR, and western blotting
P. Riihilä, L. Nissinen, M. Farshchian, A. Kivisaari, R. Ala‐aho, M. Kallajoki, R. Grénman, S. Meri, S. Peltonen, J. Peltonen, V. Kähäri   +10 more
semanticscholar   +4 more sources

Complement-Mediated Virus Infectivity Neutralisation by HLA Antibodies Is Associated with Sterilising Immunity to SIV Challenge in the Macaque Model for HIV/AIDS. [PDF]

, 2014
Sterilising immunity is a desired outcome for vaccination against human immunodeficiency virus (HIV) and has been observed in the macaque model using inactivated simian immunodeficiency virus (SIV).
A Morner, Adriano Boasso, AJ Hessell, B Hahn, BL Sullivan, BL Sullivan, D Montefiori, DH Barouch, EG Hulskotte, EJ Stott, EJ Stott, EJ Stott, EJ Stott, EJ Stott, G Hunsmann, GB Karlsson Hedestam, GT Spear, GT Spear, H Akari, H Jiang, H Mouquet, H Mouquet, H Stoiber, HX Liao, J Chojnacki, J Rose, James Stott, JF Bower, JG Leith, JR Carlson, JR Mascola, LO Arthur, LO Arthur, M Gardner, M Huber, M Murphey-Corb, M Page, M Spruth, Mark Hassall, Mark Page, Mark Robinson, Martin Cranage, MP Cranage, MP Cranage, Neil Almond, P Putkonen, QJ Sattentau, R Hofmann-Lehmann, R Le Grand, RC Desrosiers, RP Johnson, Ruby Quartey-Papafio, S Ranjbar, S Willey, SW Barnett, TW Baba, VM Hirsch, WL Chan, WL Chan, X Wei, Y Wang, YML Valim   +61 more
core   +10 more sources

Analysis of Binding Sites on Complement Factor I That Are Required for Its Activity [PDF]

Journal of Biological Chemistry, 2010
The central complement inhibitor factor I (FI) degrades activated complement factors C4b and C3b in the presence of cofactors such as C4b-binding protein, factor H, complement receptor 1, and membrane cofactor protein. FI is a serine protease composed of two chains.
Sara C. Nilsson, Gelu M. Nita, Lisa Månsson, Tom W.L. Groeneveld, Leendert A. Trouw, Bruno O. Villoutreix, Anna M. Blom   +6 more
openalex   +6 more sources

Complement factor I upregulates expression of matrix metalloproteinase‐13 and ‐2 and promotes invasion of cutaneous squamous carcinoma cells

Experimental Dermatology, 2021
The incidence of cutaneous squamous cell carcinoma (cSCC) is increasing globally. Here, we have studied the functional role of complement factor I (CFI) in the progression of cSCC.
Pegah Rahmati Nezhad, P. Riihilä, M. Piipponen, M. Kallajoki, S. Meri, L. Nissinen, V. Kähäri   +6 more
semanticscholar   +1 more source

CipA mediates complement resistance of Acinetobacter baumannii by formation of a factor I-dependent quadripartite assemblage

Frontiers in Immunology, 2022
Multidrug-resistant Acinetobacter baumannii is known to be one of the leading pathogens that cause severe nosocomial infections. To overcome eradication by the innate immune system during infection, A.
Julia I. Ries, Marie Heß, Noura Nouri, Thomas A. Wichelhaus, Stephan Göttig, Franco H. Falcone, Peter Kraiczy   +6 more
doaj   +1 more source