Hereditary complement factor I deficiency [PDF]
QJM: An International Journal of Medicine, 1994 We describe four cases (from three families) of hereditary factor I deficiency, bringing the total number of cases now reported to 23. In one family there are two affected siblings: one has suffered recurrent pyogenic infections; the other is asymptomatic.
VYSE, T.J. +7 more
openaire +5 more sources
Profiling Complement System Components in Primary CNS Vasculitis
Cells, 2021 Complement activation has been implicated in the pathogenesis of many vasculitic syndromes such as anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides.
Milani Deb-Chatterji +6 more
doaj +1 more source
Diagnostics, 2021 The role and diagnostic value of the synovial complement system in patients with low-grade periprosthetic joint infection (PJI) are unclear. We sought to evaluate, for the first time, the usefulness of synovial complement factors in these patients by ...
Frank Sebastian Fröschen +6 more
doaj +1 more source
Complement, but Not Platelets, Plays a Pivotal Role in the Outcome of Mucormycosis In Vivo
Journal of Fungi, 2023 Background: Mucormycetes, a heterogeneous group of fungi, induce a life-threatening disease called mucormycosis. Immune deficiencies represent a major risk factor; hence, we wanted to illuminate the role of complement and platelets in the defense against
Verena Harpf +8 more
doaj +1 more source
Components of the Complement Cascade Differ in Polycystic Ovary Syndrome [PDF]
, 2022 Complement pathway proteins are reported to be increased in polycystic ovary syndrome (PCOS) and may be affected by obesity and insulin resistance. To investigate this, a proteomic analysis of the complement system was undertaken, including inhibitory ...
Atkin, Stephen L. +3 more
core +1 more source
Characteristics and management of thrombotic microangiopathy in kidney transplantation
Korean Journal of Transplantation, 2023 Thrombotic microangiopathy is not a rare complication of kidney transplantation and is characterized by microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury with extensive thrombosis of the arterioles and capillaries.
Wonyong Cho +3 more
doaj +1 more source
Complotype affects the extent of down-regulation by Factor I of the C3b feedback cycle in vitro. [PDF]
, 2014 Sera from a large panel of normal subjects were typed for three common polymorphisms, one in C3 (R102G) and two in Factor H (V62I and Y402H), that influence predisposition to age-related macular degeneration and to some forms of kidney disease.
Buchberger, A +8 more
core +1 more source
Autoantibodies to complement components in C3 glomerulopathy and atypical hemolytic uremic syndrome. [PDF]
, 2014 The alternative pathway of complement is implicated in the pathogenesis of several renal diseases, such as atypical hemolytic uremic syndrome, dense deposit disease and other forms of C3 glomerulopathy.
Józsi, Mihály +6 more
core +1 more source
Cleavage of Complement C3b to iC3b on the Surface of Staphylococcus aureus Is Mediated by Serum Complement Factor I [PDF]
Infection and Immunity, 2004 ABSTRACTComplement-mediated opsonization ofStaphylococcus aureusbearing the dominant capsule serotypes, serotypes 5 and 8, remains incompletely understood. We have previously shown that complement plays a vital role in the efficient phagocytosis of a serotype 5S.
K. Cunnion, P. Hair, E. Buescher
semanticscholar +4 more sources
Complement regulator CD46: Genetic variants and disease associations [PDF]
, 2015 Membrane cofactor protein (MCP; CD46) is an ubiquitously expressed complement regulatory protein that protects host cells from injury by complement.
Atkinson, John P, Liszewski, M. Kathryn
core +2 more sources