Results 41 to 50 of about 1,284,220 (297)

Deletion of complement factor H-related genes CFHR1 and CFHR3 is associated with atypical hemolytic uremic syndrome. [PDF]

PLoS Genetics, 2007
Atypical hemolytic uremic syndrome (aHUS) is associated with defective complement regulation. Disease-associated mutations have been described in the genes encoding the complement regulators complement factor H, membrane cofactor protein, factor B, and ...
Peter F Zipfel, Matthew Edey, Stefan Heinen, Mihály Józsi, Heiko Richter, Joachim Misselwitz, Bernd Hoppe, Danny Routledge, Lisa Strain, Anne E Hughes, Judith A Goodship, Christoph Licht, Timothy H J Goodship, Christine Skerka   +13 more
doaj   +1 more source

Induction of chromosome shattering by ultraviolet light and caffeine: The influence of different distributions of photolesions [PDF]

, 1986
Cells of synchonized and of asynchronously growing cultures of a V79 Chinese hamster line were microirradiated with a low poweer laser-UV-microbeam of wavelength 257 nm.
Barranco, Brenner, Cornelis, Cremer, Cremer, Cremer, Cremer, Cremer, Cremer, Cremer, Cremer, Cremer, Cremer, Cremer, Cremer, Cremer, Cremer, Cremer, González-Fernández, Hens, Kihlman, Kihlman, Kihlman, Kihlman, Lau, Lehmann, Moreno, Nilsson, Painter, Painter, Raith, Rappold, Roberts, Schardin, Sedgwick, Setlow, Stack, Steward, Tatsumi, Tobey, Tomulin, Zorn, Zorn   +42 more
core   +1 more source

Autoantibodies to complement components in C3 glomerulopathy and atypical hemolytic uremic syndrome. [PDF]

, 2014
The alternative pathway of complement is implicated in the pathogenesis of several renal diseases, such as atypical hemolytic uremic syndrome, dense deposit disease and other forms of C3 glomerulopathy.
Józsi, Mihály, Lopez-Trascasa, M., Nozal, P., Prohászka, Zoltán, Reuter, S., Sanchez-Corral, P., Uzonyi, Barbara   +6 more
core   +1 more source

Complement Factor I Promotes Progression of Cutaneous Squamous Cell Carcinoma [PDF]

Journal of Investigative Dermatology, 2015
The incidence of cutaneous squamous cell carcinoma (cSCC) is rising worldwide. We have examined the role of complement components in the progression of cSCC. Analysis of cSCC cell lines (n=8) and normal human epidermal keratinocytes (n=11) with whole transcriptome profiling (SOLiD), quantitative real-time reverse transcriptase-PCR, and western blotting
Kivisaari Atte Kalervo, Peltonen Juha Tuomas Kalervo, Nissinen Liisa Maria, Kallajoki Markku, Farshchian Mehdi, Riihilä Pilvi Marketta, Grenman Reidar Axel, Peltonen Sirkku Anneli, Kähäri Veli-Matti, Meri Seppo, Kivisaari Atte, Nissinen Liisa, Kallajoki Markku, Farshchian Mehdi, Riihilä Pilvi, Grenman Reidar, Peltonen Sirkku, Kähäri Veli-Matti, Meri Seppo   +18 more
openaire   +3 more sources

Phosphorylation of complement factor C3 in vivo [PDF]

Biochemical Journal, 1989
Complement factor C3, the central protein of the complement system, was found to be phosphorylated both in EDTA- and heparin-anticoagulated whole blood and in coagulating blood. Complement S protein (vitronectin) was also found to be phosphorylated under these conditions.
openaire   +2 more sources

Elevated Plasma Complement Factors in CRB1-Associated Inherited Retinal Dystrophies [PDF]

Investigative Ophthalmology & Visual Science, 2023
AbstractObjectiveTo determine the profile of inflammation-related proteins and complement system factors in serum ofCRB1-associated inherited retinal dystrophies (CRB1-IRDs).DesignA case-control study.Subjects, Participants, and/or ControlsA cohort of 30 DutchCRB1-IRD patients and 29 Dutch healthy controls (HC) (Cohort I), and a second cohort of ...
Lude Moekotte, Joke de Boer, Sanne Hiddingh, Aafke de Ligt, Xuan‐Thanh‐An Nguyen, Carel B. Hoyng, Chris F. Inglehearn, Martin McKibbin, Tina M. Lamey, Jennifer A. Thompson, Fred K. Chen, Terri L. McLaren, Alaa AlTalbishi, Daan M. Panneman, Erica G. M. Boonen, Sandro Banfi, Béatrice Bocquet, Isabelle Meunier, Elfride De Baere, Robert K. Koenekoop, Monika Ołdak, Carlo Rivolta, Lisa Roberts, Raj Ramesar, R. Strupaite-Sileikiene, Susanne Kohl, G. Jane Farrar, Marion van Vugt, Jessica van Setten, Susanne Roosing, L. Ingeborgh van den Born, Camiel J.F. Boon, Maria M. van Genderen, Jonas J. W. Kuiper   +33 more
openalex   +7 more sources

Influence of Glucose on Candida albicans and the Relevance of the Complement FH-Binding Molecule Hgt1 in a Murine Model of Candidiasis

Antibiotics, 2022
Candidiasis is common in diabetic patients. Complement evasion is facilitated by binding complement factor H (FH). Since the expression of high-affinity glucose transporter 1 (Hgt1), a FH-binding molecule, is glucose-dependent, we aimed to study its ...
Verena Harpf, Samyr Kenno, Günter Rambach, Verena Fleischer, Nadia Parth, Christian X. Weichenberger, Peter Garred, Silke Huber, Cornelia Lass-Flörl, Cornelia Speth, Reinhard Würzner   +10 more
doaj   +1 more source

Complement evasion factor (CEF), a novel immune evasion factor of Streptococcus pyogenes [PDF]

Virulence, 2022
Streptococcus pyogenes, a leading human pathogen, is responsible for a wide range of diseases, including skin and soft tissue infections and severe invasive diseases. S. pyogenes produces a large arsenal of virulence factors, including several immune evasion factors. We have identified an open reading frame (spy0136) in the S.
Haniyeh Aghababa, Yi Tian Ting, Devaki Pilapitiya, Jacelyn M.S. Loh, Paul G. Young, Thomas Proft   +5 more
openaire   +3 more sources

Inhibition of c3 convertase activity by hepatitis C virus as an additional lesion in the regulation of complement components. [PDF]

PLoS ONE, 2014
We have previously reported that in vitro HCV infection of cells of hepatocyte origin attenuates complement system at multiple steps, and attenuation also occurs in chronically HCV infected liver, irrespective of the disease stage. However, none of these
Hangeun Kim, Keith Meyer, Adrian M Di Bisceglie, Ranjit Ray   +3 more
doaj   +1 more source

Effect of Heme Oxygenase-1 Depletion on Complement Regulatory Proteins Expression in the Rat

Antioxidants, 2022
Heme oxygenase has been implicated in the regulation of various immune responses including complement activation. Using a transgenic rat model of HO-1 depletion, the present study assessed the effect of HO-1 absence on the expression of complement ...
Maria G. Detsika, Eirini Theochari, Kostas Palamaris, Harikleia Gakiopoulou, Elias A. Lianos   +4 more
doaj   +1 more source