Results 51 to 60 of about 2,390,880 (343)

Atypical hemolytic uremic syndrome : update on the complement system and what is new [PDF]

, 2010
Atypical hemolytic uremic syndrome (aHUS) is a rare disease of microangiopathic hemolytic anemia, thrombocytopenia, and predominant renal impairment. It is characterized by the absence of Shiga toxin-producing bacteria as a triggering factor.
Dickenmann, Michael, Hirt-Minkowski, Patricia, Schifferli, Jürg A.   +2 more
core   +1 more source

Complement factors and reticular pseudodrusen in intermediate age-related macular degeneration staged by multimodal imaging

BMJ Open Ophthalmology, 2020
Objective Systemic activation of the complement system in intermediate age-related macular degeneration (AMD) is understudied. Moreover, links between the presence of reticular pseudodrusen (RPD) and systemic complement dysregulation have not been ...
Anne M Lynch, Alan G Palestine, Brandie D Wagner, Jennifer L Patnaik, Ashley A Frazier-Abel, Marc T Mathias, Frank S Siringo, Vernon Michael Holers, Naresh Mandava   +8 more
doaj   +1 more source

Genetic variation in CFH predicts phenytoin-induced maculopapular exanthema in European-descent patients [PDF]

, 2017
Objective To characterize, among European and Han Chinese populations, the genetic predictors of maculopapular exanthema (MPE), a cutaneous adverse drug reaction common to antiepileptic drugs.
Auce, Pauls, Avbersek, Andreja, Baum, Larry, Becker, Felicitas, Brodie, Martin J., Canadian Pharmacogenomics Network for Drug Safety, Carleton, Bruce C., Cavalleri, Gianpiero L., Cendes, Fernando, Cherny, Stacey, Coppola, Antonietta, Delanty, Norman, Depondt, Chantal, EPIGEN Consortium, EpiPGX Consortium, Francis, Ben, Gudmundsson, Lárus J., Gui, Hongsheng, Heggeli, Kristin, Ingason, Andrés, International League Against Epilepsy Consortium on Complex Epil, Johnson, Michael R., Klein, Karl Martin, Koeleman, Bobby P.C., Krause, Roland, Krenn, Martin, Kunz, Wolfram S., Kwan, Patrick, Kwok, Maxwell, Langley, Sarah R., Lerche, Holger, Leu, Costin, Liao, Wei-ping, Lopes-Cendes, Iscia, Marson, Anthony G., McCormack, Mark, O'Brien, Terence J., Pirmohamed, Munir, Rau, Sarah, Ross, Colin J.D, Sander, Josemir W., Secolin, Rodrigo, Shear, Neil, Sills, Graeme J., Sisodiya, Sanjay M., Speed, Doug, Stefánsson, Kári, Striano, Pasquale, Weckhuysen, Sarah, Wolking, Stefan, Wright, Galen E.B., Yasuda, Clarissa, Zara, Federico, Zhang, Eunice J.   +53 more
core   +7 more sources

Complement‐activating ability of leucocytes from patients with‘qc complement factor I deficiency [PDF]

Immunology, 1997
Previous studies from this laboratory have shown that normal peripheral blood B cells are capable of activating complement via the alternative pathway (AP), that the activation is associated with complement receptor type 2 (CR2) expression, and that erythrocytes at normal blood levels partially inhibit the activation.
H. V. Marquart, R. G. Q. Leslie, J M Rasmussen   +2 more
openaire   +3 more sources

Clumping Factor A Interaction with Complement Factor I Increases C3b Cleavage on the Bacterial Surface of Staphylococcus aureus and Decreases Complement-Mediated Phagocytosis [PDF]

Infection and Immunity, 2010
ABSTRACTThe human complement system is important in the immunological control ofStaphylococcus aureusinfection. We showed previously thatS. aureussurface protein clumping factor A (ClfA), when expressed in recombinant form, bound complement control protein factor I and increased factor I cleavage of C3b to iC3b.
P. Hair, Charlene G. Echague, Amber M Sholl, Justin A Watkins, J. Geoghegan, T. Foster, K. Cunnion   +6 more
semanticscholar   +6 more sources

Phosphorylation of complement factor C3 in vivo [PDF]

Biochemical Journal, 1989
Complement factor C3, the central protein of the complement system, was found to be phosphorylated both in EDTA- and heparin-anticoagulated whole blood and in coagulating blood. Complement S protein (vitronectin) was also found to be phosphorylated under these conditions.
openaire   +3 more sources

Mutations in components of complement influence the outcome of Factor I-associated atypical hemolytic uremic syndrome [PDF]

, 2010
Genetic studies have shown that mutations of complement inhibitors such as membrane cofactor protein, Factors H, I, or B and C3 predispose patients to atypical hemolytic uremic syndrome (aHUS).
Bienaime, Frank, Blom, Anna,, Blouin, Jacques, Dragon-Durey, Marie-Agnes, Fremeaux-Bacchi, Veronique, Jablonski, Mathieu, Kwan, Wing H., Loirat, Chantal, Lund University., Lund University., Nilsson, Sara,, Rameix-Welti, Marie-Anne, Regnier, Catherine H., Renault, Nicolas, Sautes-Fridman, Catherine, Villoutreix, Bruno O.   +15 more
core   +1 more source

Deletion of the Zinc Transporter Lipoprotein AdcAII Causes Hyperencapsulation of Streptococcus pneumoniae Associated with Distinct Alleles of the Type I Restriction-Modification System. [PDF]

, 2020
The capsule is the dominant Streptococcus pneumoniae virulence factor, yet how variation in capsule thickness is regulated is poorly understood. Here, we describe an unexpected relationship between mutation of adcAII, which encodes a zinc uptake ...
Arioli, Bayle, Bentley, Brown, Brown, Brown, Brown, Dintilhac, Domenech, Domenech de Cellès, Donini, Eijkelkamp, Faille, Geno, Giammarinaro, Giefing-Kröll, Gillespie, Hammerschmidt, Hathaway, Henrichsen, Hyams, Hyams, James, Johnston, Junges, Kietzman, Kim, Kim, Kohler, Li, Loisel, Loisel, Manso, Morona, Nelson, Oggioni, Oliver, Plumptre, Rowland, Sanchez, Sanchez, Schaffner, Trappetti, Ulijasz, Ventura, Weiser, Wilson, Wilson, Wu, Yadav, Yahiaoui, Yother   +51 more
core   +3 more sources

Inhibition of c3 convertase activity by hepatitis C virus as an additional lesion in the regulation of complement components. [PDF]

PLoS ONE, 2014
We have previously reported that in vitro HCV infection of cells of hepatocyte origin attenuates complement system at multiple steps, and attenuation also occurs in chronically HCV infected liver, irrespective of the disease stage. However, none of these
Hangeun Kim, Keith Meyer, Adrian M Di Bisceglie, Ranjit Ray   +3 more
doaj   +1 more source

Influence of Glucose on Candida albicans and the Relevance of the Complement FH-Binding Molecule Hgt1 in a Murine Model of Candidiasis

Antibiotics, 2022
Candidiasis is common in diabetic patients. Complement evasion is facilitated by binding complement factor H (FH). Since the expression of high-affinity glucose transporter 1 (Hgt1), a FH-binding molecule, is glucose-dependent, we aimed to study its ...
Verena Harpf, Samyr Kenno, Günter Rambach, Verena Fleischer, Nadia Parth, Christian X. Weichenberger, Peter Garred, Silke Huber, Cornelia Lass-Flörl, Cornelia Speth, Reinhard Würzner   +10 more
doaj   +1 more source