Translational Psychiatry, 2023 Immunological/inflammatory factors are implicated in the development of psychosis. Complement is a key driver of inflammation; however, it remains unknown which factor is better at predicting the onset of psychosis.
TianHong Zhang +12 more
doaj +1 more source
Integration of an Active Filter and a Single-Phase AC/DC Converter with Reduced Capacitance Requirement and Component Count [PDF]
, 2015 Existing methods of incorporating an active filter into an AC/DC converter for eliminating electrolytic capacitors usually require extra power switches. This inevitably leads to an increased system cost and degraded energy efficiency.
Hui, SYR, Li, S, Qi, W, Tan, SC
core +1 more source
Atypical hemolytic-uremic syndrome due to complement factor I mutation. [PDF]
World J Nephrol, 2017 Atypical hemolytic-uremic syndrome (aHUS) is a rare disease of complement dysregulation leading to thrombotic microangiopathy (TMA). Renal involvement and progression to end-stage renal disease are common in untreated patients. We report a 52-year-old female patient who presented with severe acute kidney injury, microangiopathic hemolytic anemia, and ...
Almalki AH +5 more
europepmc +3 more sources
Thrombotic microangiopathies: thrombotic thrombocytopenic purpura / hemolytic uremic syndrome [PDF]
, 2010 Thrombotic microangiopathies (TMAs) are pathological conditions characterized by generalized microvascular occlusion by platelet thrombi, thrombocytopenia, and microangiopathic hemolytic anemia.
Mastroianni Kirsztajn, Gianna +1 more
core +2 more sources
Disseminated gonococcal infection secondary to a rare homozygous mutation resulting in complement factor I deficiencyFactor I deficiency and gonococcus [PDF]
Journal of Human ImmunityWe report a case of disseminated gonococcal infection linked to complement factor I (FI) deficiency, with a prior vasculitis-like episode. FI deficiency should be suspected in the setting of complement consumption, characterized by low levels of multiple
Marianna Almpani +8 more
doaj +1 more source
Novel factors of Anopheles gambiae haemocyte immune response to Plasmodium berghei infection [PDF]
, 2016 Background Insect haemocytes mediate cellular immune responses (e.g., phagocytosis) and contribute to the synthesis of humoral immune factors. In previous work, a genome-wide molecular characterization of Anopheles gambiae circulating haemocytes was ...
Christophides, GK, Lombardo, F
core +3 more sources
The story of complement factor I
Immunobiology, 2019 Factor I was first discovered in 1966. Its importance became apparent with the description of the original Factor I deficient patient in Boston in 1967. This patient presented with a hyperactive alternative complement pathway resulting in secondary complement deficiency due to continuous complement consumption.
openaire +3 more sources
Hereditary complement factor I deficiency [PDF]
, 2017 Summary We describe four cases (from three families) of hereditary factor I deficiency, bringing the total number of cases now reported to 23. In one family there are two affected siblings: one has suffered recurrent pyogenic infections; the other is ...
ATHANASSIOU, P. +7 more
core
Two patients with history of STEC-HUS, posttransplant recurrence and complement gene mutations [PDF]
, 2013 Hemolytic uremic syndrome (HUS) is a disease of microangiopathic hemolytic anemia, thrombocytopenia and acute renal failure. About 90% of cases are secondary to infections by Escherichia coli strains producing Shiga-like toxins (STEC-HUS), while 10% are ...
Alberti, M. +8 more
core +1 more source
Complement factor I: Regulatory nexus, driver of immunopathology, and therapeutic
Immunobiology, 2023 Complement factor I (FI) is the nexus for classical, lectin and alternative pathway complement regulation. FI is an 88 kDa plasma protein that circulates in an inactive configuration until it forms a trimolecular complex with its cofactor and substrate whereupon a structural reorganization allows the catalytic triad to cleave its substrates, C3b and ...
T.M. Hallam +3 more
openaire +3 more sources