Results 81 to 90 of about 1,866,008 (218)
PLoS Neglected Tropical DiseasesBackgroundNumerous studies indicate a potential protective role of helminths in diabetes mellitus (DM) progression. The complement system, vital for host defense, plays a crucial role in tissue homeostasis and immune surveillance. Dysregulated complement
Anuradha Rajamanickam +8 more
doaj +1 more source
Atypical hemolytic uremic syndrome
Orphanet Journal of Rare Diseases, 2011 Hemolytic uremic syndrome (HUS) is defined by the triad of mechanical hemolytic anemia, thrombocytopenia and renal impairment. Atypical HUS (aHUS) defines non Shiga-toxin-HUS and even if some authors include secondary aHUS due to Streptococcus pneumoniae
Frémeaux-Bacchi Véronique +1 more
doaj +1 more source
Molecular Oncology, EarlyView.MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin +14 more
wiley +1 more source
Total resummation of leading logarithms vs standard description of the Polarized DIS [PDF]
arXiv, 2006 Total resummation of leading logarithms of x contributing to the spin-dependent structure function g_1 ensures its steep rise at small x. DGLAP lacks such a resummation. Instead, the DGLAP expressions for g_1 are complemented with special phenomenological fits for the initial parton densities.
arxiv
Molecular and functional profiling unravels targetable vulnerabilities in colorectal cancer
Molecular Oncology, EarlyView.We used whole exome and RNA‐sequencing to profile divergent genomic and transcriptomic landscapes of microsatellite stable (MSS) and microsatellite instable (MSI) colorectal cancer. Alterations were classified using a computational score for integrative cancer variant annotation and prioritization.
Efstathios‐Iason Vlachavas +15 more
wiley +1 more source
Complement factor I: Regulatory nexus, driver of immunopathology, and therapeutic.
Immunobiology, 2023 T. Hallam +3 more
semanticscholar +1 more source
How Escherichia coli Circumvent Complement-Mediated Killing
Frontiers in Immunology, 2017 Complement is a crucial arm of the innate immune response against invading bacterial pathogens, and one of its main functions is to recognize and destroy target cells.
Angela S. Barbosa +2 more
doaj +1 more source
When Ideal-based Zero-divisor Graphs are Complemented or Uniquely Complemented [PDF]
arXiv, 2015 Let $R$ be a commutative ring with nonzero identity and $I$ a proper ideal of $R$. The {\it ideal-based zero-divisor graph} of $R$ with respect to the ideal $I$, denoted by $\Gamma_I(R)$, is the graph on vertices $\{x \in R\setminus I \mid xy\in I$ for some $y\in R\setminus I \}$, where distinct vertices $x$ and $y$ are adjacent if and only if $xy\in I$
arxiv
Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression
Molecular Oncology, EarlyView.Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park +6 more
wiley +1 more source
Molecular Oncology, EarlyView.CircCCNB1 expression is down‐regulated in nasopharyngeal carcinoma (NPC); thus, less NF90 protein is bound to circCCNB1 and more binds to pri‐miRNAs, blocking their (pri‐miRNAs) binding to DGCR8 and inhibiting the processing and generation of miR‐15b‐5p/miR‐7‐1‐3p. Furthermore, decreased miR‐15b‐5p/miR‐7‐1‐3p promotes the expression of the target genes
Chunmei Fan +6 more
wiley +1 more source