Results 241 to 250 of about 38,814 (311)

Ascorbic Acid Modulates Collagen Properties in Glucocorticoid‐Induced Osteoporotic Bone: Insights into Chemical, Mechanical, and Biological Regulation

open access: yesAdvanced Healthcare Materials, EarlyView.
Osteoporosis from long‐term glucocorticoid (GIOP) use elevates susceptibility to fracture. This study shows GCs impair ascorbic acid (AA) metabolism in osteoblasts, collagen synthesis and extracellular matrix integrity. AA enhanced collagen biochemical and mechanical properties and restored osteoblast and endothelial function. These findings underscore
Micaila DE Curtis   +19 more
wiley   +1 more source

Nose-to-Brain Delivery of Chlorella vulgaris Extracellular Vesicles for Antidepressant Effects. [PDF]

open access: yesJ Extracell Vesicles
Jin K   +8 more
europepmc   +1 more source

Precise Control of Drug Release in Machine Learning‐Designed Antibody‐Eluting Implants for Postoperative Scarring Inhibition in Glaucoma

open access: yesAdvanced Healthcare Materials, EarlyView.
We developed a micro‐sized, biocompatible implant for postoperative sustained delivery of anti‐fibrotic antibodies in glaucoma surgery. Machine learning‐guided optimization of polymer composition, implant geometry, and porosity enabled precise control of drug release.
Mengqi Qin   +5 more
wiley   +1 more source

A Microphysiological Interface of Skeletal Myobundles and Inflamed Adipose Tissue for Recapitulating Muscle Dysfunction in an Obese Microenvironment

open access: yesAdvanced Healthcare Materials, EarlyView.
A human cell‐based microphysiological system integrates engineered muscle tissues with an inflamed adipose–macrophage niche to model obese microenvironment‐induced muscle dysfunction. Muscle contraction is quantified by pillar deflection coupled with computational stiffness estimation. Secretome and transcriptomic profiling reveal inflammation‐mediated
Seunggyu Kim   +16 more
wiley   +1 more source

A fixed brain seeded amplification assay to complement neuropathological prion disease diagnosis. [PDF]

open access: yesJ Neuropathol Exp Neurol
Lewis V   +7 more
europepmc   +1 more source

Vaccine-induced responses to R21/Matrix-M - an analysis of samples from a phase 1b age de-escalation, dose-escalation trial. [PDF]

open access: yesFront Immunol
Bundi C   +15 more
europepmc   +1 more source

Cave-Associated Histoplasmosis Outbreak Among Travelers Returning from Costa Rica - Georgia, Texas, and Washington, December 2024-January 2025. [PDF]

open access: yesMMWR Morb Mortal Wkly Rep
Ghai RR   +15 more
europepmc   +1 more source

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