Results 91 to 100 of about 3,236,190 (349)

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Complement Receptor 2 Is Expressed in Neural Progenitor Cells and Regulates Adult Hippocampal Neurogenesis

Journal of Neuroscience, 2011
Injury and inflammation are potent regulators of adult neurogenesis. As the complement system forms a key immune pathway that may also exert critical functions in neural development and neurodegeneration, we asked whether complement receptors regulate ...
M. Moriyama, Takeshi Fukuhara, Markus Britschgi, Yingbo He, R. Narasimhan, Saul A. Villeda, H. Molina, B. Huber, M. Holers, T. Wyss-Coray   +9 more
semanticscholar   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Proteomics identifies complement protein signatures in patients with primary biliary cholangitis

European Journal of Medical Research
Primary biliary cholangitis (PBC) is a chronic autoimmune liver disease lacking reliable biomarkers for diagnosis or prognosis. To identify plasma complement biomarkers that improve diagnosis and prognosis of PBC.
Xiaolin Ma, Hang Dong, Junming Han, Ming Han, Teng Zhang, Meng Zhou, Xiude Fan, Luna Liu, Zhen Wang   +8 more
doaj   +1 more source

Lack of evidence from studies of soluble protein fragments that Knops blood group polymorphisms in complement receptor-type 1 are driven by malaria.

PLoS ONE, 2012
Complement receptor-type 1 (CR1, CD35) is the immune-adherence receptor, a complement regulator, and an erythroid receptor for Plasmodium falciparum during merozoite invasion and subsequent rosette formation involving parasitized and non-infected ...
Patience B Tetteh-Quarcoo, Christoph Q Schmidt, Wai-Hong Tham, Richard Hauhart, Haydyn D T Mertens, Arthur Rowe, John P Atkinson, Alan F Cowman, J Alexandra Rowe, Paul N Barlow   +9 more
doaj   +1 more source

A Review: Does Complement or the Contact System Have a Role in Protection or Pathogenesis of COVID-19?

Pulmonary Therapy, 2020
Introduction COVID-19 presentation may include a profound increase in cytokines and associated pneumonia, rapidly progressing to acute respiratory distress syndrome (ARDS). This so-called cytokine storm often leads to refractory edema, respiratory arrest,
Natella Maglakelidze, Kristen M. Manto, Timothy J. Craig   +2 more
doaj   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Complement activity and autophagy are dysregulated in the lungs of patients with nonresolvable COVID-19 requiring lung transplantation

Respiratory Research
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-induced coronavirus disease 2019 (COVID-19) pandemic has challenged the current understanding of the complement cascade mechanisms of host immune responses during infection-induced ...
Pooja Shivshankar, Stacey L. Mueller-Ortiz, Aleksey Y. Domozhirov, Weizhen Bi, Scott D. Collum, Marie-Francoise Doursout, Manish Patel, Isabella N. LeFebvre, Bindu Akkanti, Simon Yau, Howard J. Huang, Rahat Hussain, Harry Karmouty-Quintana   +12 more
doaj   +1 more source

Complement Receptor Type 1 Suppresses Human B Cell Functions in SLE Patients

Journal of Immunology Research, 2016
Complement receptors (CRs) play an integral role in innate immunity and also function to initiate and shape the adaptive immune response. Our earlier results showed that complement receptor type 1 (CR1, CD35) is a potent inhibitor of the B cell receptor-
Mariann Kremlitzka, Bernadett Mácsik-Valent, Anna Polgár, Emese Kiss, Gyula Poór, Anna Erdei   +5 more
doaj   +1 more source

Complement Factor H Modulates Splenic B Cell Development and Limits Autoantibody Production

Frontiers in Immunology, 2019
Complement factor H (CFH) has a pivotal role in regulating alternative complement activation through its ability to inhibit the cleavage of the central complement component C3, which links innate and humoral immunity.
Máté G. Kiss, Máté G. Kiss, Mária Ozsvár-Kozma, Mária Ozsvár-Kozma, Florentina Porsch, Florentina Porsch, Laura Göderle, Laura Göderle, Nikolina Papac-Miličević, Nikolina Papac-Miličević, Barbara Bartolini-Gritti, Barbara Bartolini-Gritti, Dimitrios Tsiantoulas, Dimitrios Tsiantoulas, Matthew C. Pickering, Christoph J. Binder, Christoph J. Binder   +16 more
doaj   +1 more source