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Complement Receptors in Neutrophils

Critical Reviews™ in Immunology, 1995
Human neutrophils contain numerous intracellular granules and vesicles that are exocytosed in a hierarchic manner on stimulation of the neutrophil with inflammatory mediators. Secretory vesicles are mobilized completely to the plasma membrane when neutrophils are stimulated with inflammatory mediators in nanomolar concentrations. There is evidence that
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Complement receptor structure and function

Immunology Today, 1985
Membrane complement receptors (CRs) are now recognized as important cell-bound components of the complement system and research into the structure and function of complement receptors is one of the main thrusts of current complement research.
G D, Ross, J P, Atkinson
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Assays for Membrane Complement Receptors

Current Protocols in Immunology, 1994
AbstractLeukocytes express several types of receptors for activated products of the complement (C) system. This unit describes assays for a subset of these receptors: those specific for fixed fragments of C3 (CR1, CR2, CR3, and CR4). Although the assays have been designed for tests of human C receptors, they can often be carried out with rodent (e.g ...
Lynda D, O'Rear, Gordon D, Ross
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Complement Receptors in HIV Infection

Current Molecular Medicine, 2002
Similar to other pathogens, HIV can directly activate the complement pathway even in the absence of antibodies. During and after seroconversion, HIV-specific antibodies enhance the activation of complement and increase deposition of complement fragments on virions dramatically.
Susi, Doepper   +4 more
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Complement factors and their receptors

Immunopharmacology, 1997
In summary, recent advances in molecular cloning of anaphylatoxins and the anaphylatoxin receptors add new dimensions to our investigations and understanding of the molecular mechanisms involved in anaphylatoxin action. Combining knowledge accumulated from peptide modeling of the ligands with mutagenesis studies of these ligands and their receptors ...
J A, Ember, T E, Hugli
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Complement Receptor Type 1

1992
This review will focus on the complement receptor type 1 (CR1, CD35) expressed by erythrocytes and will cover its structure, molecular biology, and function as a membrane inhibitor of complement activation. The CR1 present on phagocytic cells and lymphocytes has similar functions in regulation of complement activation and serves as a receptor ...
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Complement Receptors and B Lymphocytes

Critical Reviews™ in Immunology, 2004
Most of the biological processes depend on cell-to-cell and protein-to-cell interactions, which take place through receptors present on the cell surface. Various physiological systems are linked by such interactions, as is the case for innate and adaptative immune response.
Marie-Bernadette, Villiers   +3 more
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Complement receptors in HIV infection

Immunological Reviews, 1997
SummaryThe complement system plays an important role in the antimicrobial defense of the organism. Its components recognize a large variety of pathogens and target them for destruction, either directly by formation of a membrane attack complex or indirectly by recruiting phagocytic cells.
C, Speth, L, Kacani, M P, Dierich
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Complement Receptor 2 and Autoimmunity

2003
Complement receptor 2 (CR2/CD21) plays a major role in the immune response by linking innate and adaptive immunity to foreign pathogens and proteins. In addition, several lines of evidence strongly support a role for CR2 in the maintenance of tolerance to self-antigens.
V Michael, Holers, Susan A, Boackle
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Human complement receptor type 3

1987
Publisher Summary This chapter describes the purification of complement receptor type 3 (CR3), its assay, biosynthesis, and molecular cloning. The existence of CR3, a receptor that recognizes a fragment of the third component of complement termed iC3b, is initially based on the inability of antibodies specific for the CR1 or CR2 complement receptors ...
M A, Arnaout   +3 more
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