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Membrane complement regulatory proteins

Clinical Immunology, 2006
A number of proteins anchored on the cell surface function to protect host tissues from bystander injury when complement is activated. In humans, they include decay-accelerating factor (DAF, CD55), membrane cofactor protein (MCP, CD46), complement receptor 1 (CR1, CD35) and CD59. Although disease conditions directly attributable to abnormal function of
David D, Kim, Wen-Chao, Song
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Viral complement regulatory proteins

Immunopharmacology, 1999
The inactivation of complement provides cells and tissues critical protection from complement-mediated attack and decreases the associated recruitment of other inflammatory mediators. In an attempt to evade the host immune response, viruses have evolved two mechanisms to acquire complement regulatory proteins.
A M, Rosengard, J M, Ahearn
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Combination effects of complement regulatory proteins and anti-complement polymer

Biochimica et Biophysica Acta (BBA) - General Subjects, 2003
We previously reported the development of a "cytomedicine" that consists of cells trapped in alginate-poly-L-lysine-alginate (APA) microcapsules and agarose microbeads. The functional cells that are entrapped in semipermeable polymer are completely isolated from cellular immune system.
Yasuo, Yoshioka   +10 more
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Tissue-specific complement inhibition by antibody-Complement Regulatory Protein (CRP) fusions utilizing Therapeutic Autoimmune reguLatOry proteiN (TALON™) platform

The Journal of Immunology, 2021
Abstract The complement system plays a major role in humoral innate immunity. Upon activation, complement proteins trigger a cascade of enzymatic events leading to the production of inflammatory mediators and membrane attack complexes. Tight regulation of complement proteins is essential for immune homeostasis due to their potency and ...
Jiwon Jung   +10 more
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