Results 101 to 110 of about 282,933 (302)

Genistein and Sex Hormone Supplementation Modulated Hepatic PPARα, δ, and γ Subtypes and STAT1 Expressions in a NASH Rat Model with Bilateral Orchidectomy

Biomedicines
Nonalcoholic steatohepatitis (NASH) is a progressive form of nonalcoholic fatty liver disease (NAFLD) that is characterized by hepatic inflammation and steatosis.
Fatist Okrit, Maneerat Chayanupatkul, Prasong Siriviriyakul, Natcha Wanpiyarat, Duangporn Werawatganon   +4 more
doaj   +1 more source

Pregnancy, risk perception and use of complementary and alternative medicine [PDF]

, 2014
Pregnancy and childbirth are events of major significance in women's lives. In western countries women are increasingly using complementary and alternative medicine during this time.
Mitchell, Mary, McClean, Stuart
core   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Effects of curcumin on oxidative stress, inflammation and apoptosis in L-arginine induced acute pancreatitis in mice

Heliyon, 2019
Background and purpose: Curcumin, an active constituent of rhizomes of Curcuma longa Linn, exhibits a variety of biological activities such as anti-inflammation and anti-oxidant.
Prasong Siriviriyakul, Thidarat Chingchit, Naruemon Klaikeaw, Maneerat Chayanupatkul, Duangporn Werawatganon   +4 more
doaj   +1 more source

Mental health and complementary and alternative medicine

, 2012
For millennia, traditional medicine systems have used a variety of natural products and therapeutic arts to treat mental disorders. Many traditional systems of medicine treated mental disorders in an energetic or spiritual model, and often sufferers were
Sarris, Jerome (R18802), Lake, James
core  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Treatment of Acute Lymphoblastic Leukemia with Multiple Relapses in a 3-Years-Old Child with 8 Years Follow-up According to Iranian Effective Medicine

Traditional and Integrative Medicine, 2017
Leukemia is the most common malignant neoplasm during the childhood and constitutes about 31% of malignancies in under-15-year-old children. We report a 3-year-old boy with acute lymphoblastic leukemia and a history of cancer complications and 9 months ...
Hassan Hajtalebi, Hassan Khani Iurigh, Hamid Reza Hajtalebi   +2 more
doaj