Results 1 to 10 of about 801,714 (279)

Novel codons in rat Pdx-1 complementary DNA [PDF]

open access: yesBMC Research Notes, 2018
Objectives Pancreatic and duodenal homeobox-1 (Pdx-1) is a homeodomain-containing transcription factor essential for pancreatic development, beta-cell differentiation and the maintenance of mature beta cell function.
Takayoshi Kiba
doaj   +2 more sources

HLA genotyping by next-generation sequencing of complementary DNA [PDF]

open access: yesBMC Genomics, 2017
Background Genotyping of the human leucocyte antigen (HLA) is indispensable for various medical treatments. However, unambiguous genotyping is technically challenging due to high polymorphism of the corresponding genomic region.
Hidenobu Segawa   +2 more
doaj   +2 more sources

Bioelectronic DNA detection of human papillomaviruses using eSensor™: a model system for detection of multiple pathogens [PDF]

open access: yesBMC Infectious Diseases, 2003
Background We used human papillomaviruses (HPV) as a model system to evaluate the utility of a nucleic acid, hybridization-based bioelectronic DNA detection platform (eSensor™) in identifying multiple pathogens.
Miller Donna L   +7 more
doaj   +4 more sources

Rapid and Sensitive Detection of Severe Acute Respiratory Syndrome Coronavirus 2 in Label-Free Manner Using Micromechanical Sensors

open access: yesSensors, 2021
Coronavirus (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been identified as a deadly pandemic. The genomic analysis of SARS-CoV-2 is performed using a reverse transcription-polymerase chain reaction (RT-PCR)
Dalal A. Aloraini   +4 more
doaj   +1 more source

Synthesis and Evaluation of MGB Polyamide-Oligonucleotide Conjugates as Gene Expression Control Compounds

open access: yesJournal of Nucleic Acids, 2023
MGB polyamide-oligonucleotide conjugates ON 1-4 with linked MGB polyamides at the 2-exocyclic amino group of a guanine base using aminoalkyl linkers were synthesized and evaluated in terms of binding affinity for complementary DNA containing the MGB ...
Kazuo Kamaike   +13 more
doaj   +1 more source

A Brief Review of Graphene-Based Biosensors Developed for Rapid Detection of COVID-19 Biomarkers

open access: yesBiosensors, 2023
The prevalence of mutated species of COVID-19 antigens has provided a strong impetus for identifying a cost-effective, rapid and facile strategy for identifying the viral loads in public places.
Narendhar Chandrasekar   +7 more
doaj   +1 more source

Design strategy of antidote sequence for bivalent aptamer: Rapid neutralization of high‐anticoagulant thrombin‐binding bivalent DNA aptamer‐linked M08 with HD22

open access: yesResearch and Practice in Thrombosis and Haemostasis, 2021
Background Bivalent thrombin‐binding aptamers (TBAs) have great potential for the treatment of thrombosis because they exhibit high anticoagulant activity, and their complementary single‐stranded DNA (ssDNA) sequences work as an antidote.
Toru Yoshitomi   +3 more
doaj   +1 more source

Self-assembled endogenous DNA nanoparticles for auto-release and expression of the eGFP gene in Bacillus subtilis

open access: yesCommunications Biology, 2022
The DNA origami design algorithm DAEDALUS is modified to design a nanoscale cube with a two-step assembly protocol, assembling 9 modules from three DNA scaffolds and the complementary staples, combined to form the DNA origami cube.
Linfeng Cao   +8 more
doaj   +1 more source

Base Orientation of Second DNA in RecA·DNA Filaments. Analysis by combination of linear dichroism and small angle neutron scattering in flow-oriented solution [PDF]

open access: yes, 1998
To gain insight into the mechanism of pairing two complementary DNA strands by the RecA protein, we have determined the nucleobase orientation of the first and the second bound DNA strands in the RecA·DNA filament by combined measurements of linear ...
Ellouze, Christine   +5 more
core   +1 more source

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