Results 11 to 20 of about 801,714 (279)

Experimental validation of determinants of UV sensitivity using synthetic DNA

Journal of Photochemistry and Photobiology, 2022
Treatment with ultraviolet (UV) light has been shown to be effective for disinfection of pathogens. For pathogenic risk management, it would be effective to estimate the UV sensitivity of unknown pathogenic microorganisms from their nucleotide sequences.
M. Otaki, Y. Higashino, Y. Yamada
doaj   +1 more source

Rapid, highly sensitive and highly specific gene detection by combining enzymatic amplification and DNA chip detection simultaneously

Sensing and Bio-Sensing Research, 2016
We have developed a novel gene detection method based on the loop-mediated isothermal amplification (LAMP) reaction and the DNA dissociation reaction on the same DNA chip surface to achieve a lower detection limit, broader dynamic range and faster ...
Koji Hashimoto, Naoko Nakamura, Keiko Ito   +2 more
doaj   +1 more source

Molecular Spiders in One Dimension [PDF]

, 2007
Molecular spiders are synthetic bio-molecular systems which have "legs" made of short single-stranded segments of DNA. Spiders move on a surface covered with single-stranded DNA segments complementary to legs.
Alberts B, Alexander S, Antal T Krapivsky P L, Antal T Krapivsky P L Mallick K, Chen N Y, Derrida B, Derrida B, Derrida B, Derrida B, Fedders P A, Howard J, Kirone Mallick, Kolomeisky A B, Liggett T M, Mobilia M Reichenbach T Hinsch H Franosch T Frey E, Olah M J Stefanovic D, P L Krapivsky, Schütz G M, Shaw L B, Spohn H, Tibor Antal, Van Kampen N G   +21 more
core   +5 more sources

Titanium Dioxide Nanoparticle-Based Interdigitated Electrodes: A Novel Current to Voltage DNA Biosensor Recognizes E. coli O157:H7. [PDF]

PLoS ONE, 2015
Nanoparticle-mediated bio-sensing promoted the development of novel sensors in the front of medical diagnosis. In the present study, we have generated and examined the potential of titanium dioxide (TiO2) crystalline nanoparticles with aluminium ...
Sh Nadzirah, N Azizah, Uda Hashim, Subash C B Gopinath, Mohd Kashif   +4 more
doaj   +1 more source

The Enhanced Sensitivity of a Porous Silicon Microcavity Biosensor Based on an Angular Spectrum Using CdSe/ZnS Quantum Dots

Sensors, 2019
To improve the detection sensitivity of porous silicon microcavity biosensors, CdSe/ZnS quantum dots are used to label complementary DNA molecules for the refractive index amplification and angular spectrum method for detection.
Rui Zhou, Zhenhong Jia, Xiaoyi Lv, Xiaohui Huang   +3 more
doaj   +1 more source

Clerocidin selectively modifies the gyrase-DNA gate to induce irreversible and reversible DNA damage [PDF]

, 2008
Clerocidin (CL), a microbial diterpenoid, reacts with DNA via its epoxide group and stimulates DNA cleavage by type II DNA topoisomerases. The molecular basis of CL action is poorly understood.
Binaschi, Borgnetto, Brown, Cambau, Champoux, Corbett, Corbett, Ferrero, Fisher, Gatto, Higgins, Kawada, L. M. Fisher, M. Dias, M. Palumbo, Marians, Maxam, McCullough, Mizuuchi, Morrison, Pan, Pan, Pan, Pan, Pan, Peden, Pozzi, Richter, Richter, Richter, Shea, X. S. Pan, Yague, Yoshida, Zechiedrich   +34 more
core   +1 more source

A highly sensitive electrochemical genosensor based on Co-porphyrin-labelled DNA [PDF]

, 2014
We report the use of Co-porphyrins as electrochemical tags for a highly sensitive and selective genosensor. An avian influenza virus-based DNA sequence characteristic of H5N1 was detected at femtomolar levels from competing non-complementary sequences ...
Grabowska, Iwona, Góra-Sochacka, Anna, Radecka, Hanna, Radecki, Jerzy, Singleton, Daniel G., Sirko, Agnieszka, Stachyra, Anna, Stulz, Eugen, Zagórski-Ostoja, Włodzimierz   +8 more
core   +1 more source

Inhibition of BRCA2 and Thymidylate Synthase Creates Multidrug Sensitive Tumor Cells via the Induction of Combined “Complementary Lethality”

Molecular Therapy: Nucleic Acids, 2013
A high mutation rate leading to tumor cell heterogeneity is a driver of malignancy in human cancers. Paradoxically, however, genomic instability can also render tumors vulnerable to therapeutic attack. Thus, targeting DNA repair may induce an intolerable
Mateusz Rytelewski, Peter J Ferguson, Saman Maleki Vareki, Rene Figueredo, Mark Vincent, James Koropatnick   +5 more
doaj   +1 more source

Structural assessment of the full-length wild-type tumor suppressor protein p53 by mass spectrometry-guided computational modeling

Scientific Reports, 2023
The tetrameric tumor suppressor p53 represents a great challenge for 3D-structural analysis due to its high degree of intrinsic disorder (ca. 40%). We aim to shed light on the structural and functional roles of p53’s C-terminal region in full-length ...
Alessio Di Ianni, Christian Tüting, Marc Kipping, Christian H. Ihling, Janett Köppen, Claudio Iacobucci, Christian Arlt, Panagiotis L. Kastritis, Andrea Sinz   +8 more
doaj   +1 more source

Complexation of norfloxacin with DNA in the presence of caffeine [PDF]

, 2006
1H NMR spectroscopy (500 MHz) has been used to quantify the complexation of the antibacterial antibiotic Norfloxacin (NOR) with DNA in the presence of Caffeine (CAF). Separate studies have been made for the self-association of NOR, its hetero-association
Davies, David B., Evstigneev, M.P., Rybakova, K.A.   +2 more
core   +1 more source