Results 61 to 70 of about 2,891,675 (191)

Real-space and real-time dynamics of CRISPR-Cas9 visualized by high-speed atomic force microscopy

open access: yesNature Communications, 2017
CRISPR RNA-guided endonuclease Cas9 recognizes and cleaves the double-stranded DNA complementary to the RNA guide. Here the authors use high-speed atomic force micropcopy (HS-AFM) to visualize the conformational dynamics of Cas9 during its DNA targeting ...
Mikihiro Shibata   +6 more
doaj   +1 more source

Alu complementary DNA is enriched in atrophic macular degeneration and triggers retinal pigmented epithelium toxicity via cytosolic innate immunity. [PDF]

open access: yesSci Adv, 2021
Fukuda S   +38 more
europepmc   +1 more source

Argonaute bypasses cellular obstacles without hindrance during target search

open access: yesNature Communications, 2019
Argonaute protein is loaded with small RNA and scans long stretch of sequences to find complementary target sites. Here, using single-molecule FRET and kinetic modelling, the authors showed that prokaryotic Argonaute protein binds target DNA loosely and ...
Tao Ju Cui   +6 more
doaj   +1 more source

Cytoplasmic synthesis of endogenous Alu complementary DNA via reverse transcription and implications in age-related macular degeneration. [PDF]

open access: yesProc Natl Acad Sci U S A, 2021
Fukuda S   +58 more
europepmc   +1 more source

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