Results 51 to 60 of about 806,056 (297)

Two Faces of NOTCH1 in Childhood Lymphoblastic T‐Cell Neoplasia: Prognostic Divergence of Mutational and Structural Aberrations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT In pediatric patients, T‐cell lymphoblastic lymphoma (T‐LBL) survival exceeds 80%. Relapse remains associated with limited curative options. Frontline treatment is largely extrapolated from T‐cell acute lymphoblastic leukemia (T‐ALL) treatment, reflecting the ongoing debate, whether both entities represent distinct diseases or variants within ...
Marie C. Heider, Amelie Alfert, Marc Hotfilder, Birgit Burkardt, Marcel te Vrugt   +4 more
wiley   +1 more source

Factors Impacting Invader-Mediated Recognition of Double-Stranded DNA

Molecules, 2022
The development of chemically modified oligonucleotides enabling robust, sequence-unrestricted recognition of complementary chromosomal DNA regions has been an aspirational goal for scientists for many decades.
Caroline P. Shepard, Raymond G. Emehiser, Saswata Karmakar, Patrick J. Hrdlicka   +3 more
doaj   +1 more source

DNA Renaturation at the Water-Phenol Interface [PDF]

, 2003
We study DNA adsorption and renaturation in a water-phenol two-phase system, with or without shaking. In very dilute solutions, single-stranded DNA is adsorbed at the interface in a salt-dependent manner.
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core   +4 more sources

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Non-homologous DNA end joining in normal and cancer cells and its dependence on break structures

Genetics and Molecular Biology, 2010
DNA double-strand breaks (DSBs) are a serious threat to the cell, for if not or miss-repaired, they can lead to chromosomal aberration, mutation and cancer.
Tomasz Poplawski, Elzbieta Pastwa, Janusz Blasiak   +2 more
doaj  

Bismuth Oxide Nanoparticles/Chitosan/Modified Electrode as Biosensor for DNA Hybridization

International Journal of Electrochemical Science, 2011
An electrochemical DNA biosensor based on nanoparticles bismuth oxide Bi2O3 for DNA immobilization and hybridization detection is presented. The nano Bi2O3/chitosan-modified gold electrode (AuE) was fabricated and oligonucleotides were immobilized onto ...
Safura Taufik, Nor Azah Yusof, Tan Wee Tee, Irmawati Ramli   +3 more
doaj   +1 more source

Deletion mutants of bacteriophage phiX174 [PDF]

, 1972
Mutants of bacteriophage phiX174 have been isolated that are less dense than wild-type phiX particles in CsCl. When mutant viral (+) strand DNA and wild-type complementary (-) strand DNA are hybridized, the resulting duplex molecules have single-stranded
Benbow, Robert M., Sinsheimer, Robert L., Zuccarelli, Anthony J.   +2 more
core  

A highly sensitive electrochemical genosensor based on Co-porphyrin-labelled DNA [PDF]

, 2014
We report the use of Co-porphyrins as electrochemical tags for a highly sensitive and selective genosensor. An avian influenza virus-based DNA sequence characteristic of H5N1 was detected at femtomolar levels from competing non-complementary sequences ...
Grabowska, Iwona, Góra-Sochacka, Anna, Radecka, Hanna, Radecki, Jerzy, Singleton, Daniel G., Sirko, Agnieszka, Stachyra, Anna, Stulz, Eugen, Zagórski-Ostoja, Włodzimierz   +8 more
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Beating the reaction limits of biosensor sensitivity with dynamic tracking of single binding events [PDF]

, 2018
The clinical need for ultrasensitive molecular analysis has motivated the development of several endpoint-assay technologies capable of single-molecule readout.
Sevenler, Derin, Trueb, Jacob, Unlu, M. Selim   +2 more
core   +2 more sources