Results 61 to 70 of about 806,056 (297)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

A flexible integrative approach based on random forest improves prediction of transcription factor binding sites [PDF]

, 2012
Transcription factor binding sites (TFBSs) are DNA sequences of 6-15 base pairs. Interaction of these TFBSs with transcription factors (TFs) is largely responsible for most spatiotemporal gene expression patterns.
Abeel, Afflerbach, Angarica, Bailey, Bart Hooghe, Bauer, Benos, Breiman, Bulyk, Burden, Calladine, Camenisch, Chen, Cho, Cordell, Davis, Dickerson, Ehret, Ernst, Frans van Roy, Friedel, Fujii, Fulton, Gama-Castro, Gardiner, Gartenberg, Gershenzon, Goodsell, Gorin, Gowrisankar, Greenbaum, Gunewardena, Hall, Hendrickson, Hu, Juo, Kajimura, Kaplan, Karas, Kel, Kim, Lavery, Lewis, Liu, Liu, Liu, Long, Lu, Lu, Lu, Lunetta, Man, Marco, Marinescu, Martinez-Hackert, Matys, Medina-Rivera, Meysman, Michel, Mokry, Morozov, Narang, Naughton, O'Flanagan, Olson, Paillard, Pan, Parker, Parvin, Pieter De Bleser, Ponomarenko, Portales-Casamar, Powell, Pudimat, Ramsey, Rohs, Rohs, Rohs, Ruiz, Satchwell, Schneider, Shakked, Sharon, Shi, Spolar, Stefan Broos, Stormo, Svozil, Thayer, Tomovic, Toro-Roman, Travers, Tullius, Wunderlich, Zhang, Zhang, Zhu   +96 more
core   +2 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Maximum pull out force on DNA hybrids [PDF]

, 2001
We discuss theoretically the force F between two colloidal particles, each of them carrying one single strand DNA. The two strands are complementary only on a finite sequence of consecutive base pairs.
Csaki, Lebrun, Lebrun, Lee, Mazzola, Pierre-Gilles de Gennes   +5 more
core   +2 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Structural mechanism of strand exchange by the RAD51 filament

eLife
Homologous recombination (HR) preserves genomic stability by repairing double-strand DNA breaks and ensuring efficient DNA replication. Central to HR is the strand-exchange reaction taking place within the three-stranded synapsis wherein a RAD51 ...
Luay Joudeh, Robert E Appleby, Joseph D Maman, Luca Pellegrini   +3 more
doaj   +1 more source

A High‐Sensitivity Circulating Nucleic Acid Sequencing Assay for Assessing Treatment Response to Alectinib in a Pediatric Patient With ALK‐Rearranged Non–Small Cell Lung Cancer

Pediatric Blood &Cancer, EarlyView.
Alberto D. Guerra, Nicholas F. Evageliou, Vandana Batra, Kristen L. Dalton, Stephanie Ortel, Usman Ashraf, Tricia R. Bhatti, Lisa J. States, Lea F. Surrey, Theodore W. Laetsch   +9 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Simulations Meet Experiment to Reveal New Insights into DNA Intrinsic Mechanics.

PLoS Computational Biology, 2015
The accurate prediction of the structure and dynamics of DNA remains a major challenge in computational biology due to the dearth of precise experimental information on DNA free in solution and limitations in the DNA force-fields underpinning the ...
Akli Ben Imeddourene, Ahmad Elbahnsi, Marc Guéroult, Christophe Oguey, Nicolas Foloppe, Brigitte Hartmann   +5 more
doaj   +1 more source