Results 51 to 60 of about 2,044,716 (227)
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Learning What Matters in FHIR Graph Generation for Synthetic Patient Trajectories
IEEE AccessWe study the generation of synthetic longitudinal patient records as FHIR graphs, representing each patient as a sequence of encounters connected to diagnoses and procedures.
Mikel Bahn +11 more
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Complementary information set codes over GF(p)
, 2018 Complementary information set codes (CIS codes) over a finite field GF(p) are closely connected to correlation-immune functions over GF(p), which are important cryptographic functions, where p is an odd prime.
이윤진, 김현진
core +1 more source
On the Design of LAS Spreading Codes
, 2002 A family of Large Area Synchronised (LAS) codes is studied, which exhibits a so-called Interference Free Window (IFW), where both the Inter Symbol Interference (ISI) and the Multiple User Interference (MAI) are suppressed, provided that the relative time
Choi, B.J., Hanzo, L
core +1 more source
International Journal of Mathematics and Mathematical SciencesFor nonzero coprime integers a and b, a positive integer l is said to be good with respect to a and b if there exists a positive integer k such that l divides ak+bk.
Somphong Jitman
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
, 2019 We study multidimensional analogues of quasi-twisted codes from different points of view. Their concatenated structure allows us to characterize self-dual and complementary-dual classes of such codes as well as to show that multidimensional quasi-twisted
Özkaya, Buket, Ling, San
core +1 more source
Cyclotomic Classes in a Product of Finite Abelian Groups and Applications
Journal of MathematicsCyclotomic classes of finite abelian groups have been extensively investigated for many decades, largely because of their nice algebraic structure and the breadth of their theoretical and practical applications.
Somphong Jitman
doaj +1 more source
A Closed-Form Hamming-Weight Variance Formula for Cyclic LCD Codes in Orthogonal Direct Sum Masking
CryptographyOrthogonal direct sum masking (ODSM) protects embedded cryptographic implementations against side-channel attacks by splitting the ambient space into a source code C carrying sensitive data and a complementary masking code D carrying fresh randomness ...
Guillermo Sosa-Gómez
doaj +1 more source