Results 61 to 70 of about 18,053 (229)
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
International Journal of Mathematics and Mathematical SciencesFor nonzero coprime integers a and b, a positive integer l is said to be good with respect to a and b if there exists a positive integer k such that l divides ak+bk.
Somphong Jitman
doaj +1 more source
World Electric Vehicle JournalThe global electric vehicle (EV) market has experienced sustained growth over the last decade; however, adoption within the commercial EV segment remains comparatively sluggish. This disparity is driven by three primary factors: the intrinsic limitations
Soham Ghosh
doaj +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Cyclotomic Classes in a Product of Finite Abelian Groups and Applications
Journal of MathematicsCyclotomic classes of finite abelian groups have been extensively investigated for many decades, largely because of their nice algebraic structure and the breadth of their theoretical and practical applications.
Somphong Jitman
doaj +1 more source
On maximum distance separable group codes with complementary duals
CoRR, 2018 9 pages, 1 ...
Saikat Roy, Satya Bagchi
openaire +2 more sources
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Self-dual and complementary dual abelian codes over Galois rings
Journal of Algebra Combinatorics Discrete Structures and Applications, 2019 Self-dual and complementary dual cyclic/abelian codes over finite fields form important classes of linear codes that have been extensively studied due to their rich algebraic structures and wide applications. In this paper, abelian codes over Galois rings are studied in terms of the ideals in the group ring ${ GR}(p^r,s)[G]$, where $G$ is ...
Somphong JİTMAN, San LİNG
openaire +7 more sources