Results 41 to 50 of about 208,635 (246)
COVID-19: a trigger for severe thrombotic microangiopathy in a patient with complement gene variant [PDF]
, 2022 Larisa Pinte +4 more
openalex +1 more source
By dawn or dusk—how circadian timing rewrites bacterial infection outcomes
FEBS Letters, EarlyView.The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo +2 more
wiley +1 more source
Control, temporal orientation, and the cross-linguistic grammar of trying
Glossa, 2017 The verb try plays a starring role in many example sentences in the control literature. But one of its most basic properties has eluded satisfying explanation: for many speakers of English, try rejects non-control infinitival complements, as in %I tried ...
Thomas Grano
doaj +2 more sources
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Anglophonia, 2007 Cet article propose une analyse de la complémentation infinitive et gérondive en anglais au moyen d’un cadre théorique fondé sur la sémantique naturelle non formelle. Le postulat de base de l’analyse est que ce sont les signifiés des formes linguistiques
Patrick Duffley
doaj +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Luciferase complementation based-detection of G-protein-coupled receptor activity
BioTechniques, 2018 Protein complementation assays (PCA) are used as pharmacological tools, enabling a wide array of applications, ranging from studies of protein–protein interactions to second messenger effects.
Hideaki Yano +3 more
doaj +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
On a Certain Lithuanian Purpose Clause Construction
Lietuvių KalbaThe article deals with the use of the Lithuanian anteriority converb in -us in a certain type of purpose clauses whose implicit subject is coreferential with the (often also implicit) main clause subject or agent (as in kad veltui neišmetus pinigų ‘in ...
Axel Holvoet
doaj +3 more sources
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source