Results 81 to 90 of about 2,497 (286)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Diachronic evolution of the subordinator kak in Russian
LinguisticsIn Russian, the subordinator kak ‘how’ is both a manner question word and an eventive complementizer. The Russian linguistic tradition explains the colexification of the two functions in terms of a semantic shift from manner as characteristic of a ...
Serdobolskaya Natalia, Kobozeva Irina
doaj +1 more source
The interpretation of [+distal] in demonstratives and complementizers. [PDF]
Linguistics, 2023 Staps C, Rooryck J.
europepmc +1 more source
Frontiers in Bioscience, 2011 The complement (C) system is a vital arm of innate immunity with many roles, including control of inflammation. This article examines the (C) system with emphasis on recent developments on complement relevant to neurobiology, in particular regarding our understanding and treatment of immune-mediated diseases.
Lawrence L, Horstman +7 more
openaire +2 more sources
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Ordering paradoxes in a cross-categorial paradigm: on syncretisms with the declarative complementizer [PDF]
, 2018 This paper shows that incorporating non-definite demonstratives into the same fseq which covers syncretisms with the declarative complementizer, discussed in Baunaz and Lander’s (2018a) work, is necessary to explain syncretic alignment and morphological
Wiland, Bartosz
core
Basque non-interrogative nola as a (de dicto) factive complementizer
, 2023 This chapter proposes an analysis of the syntax and semantics of non-V2 nola-headed embedded clauses in Basque. Such structures have a particular behavior in three main respects: (i) Contrary to its appearance, nola does not behave like a manner wh-item;
IRURTZUN, Aritz
core +1 more source