Results 51 to 60 of about 1,682,624 (248)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
The Agreement Measure γcat a Complement to γ Focused on Categorization of a Continuum [PDF]
Computational Linguistics, 2017 Agreement on unitizing, where several annotators freely put units of various sizes and categories on a continuum, is difficult to assess because of the simultaneaous discrepancies in positioning and categorizing. The recent agreement measure γ offers an overall solution that simultaneously takes into account positions and categories.
openaire +4 more sources
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Complementizer cliticization in Tagalog and English
, 1999 This paper investigates the conditions on the allomorphy of the Tagalog "linker". When the linker is used as a declarative complementizer, the affixal version has the same distribution as the null complementizer in English, while the free-standing linker
Richards, Norvin
core +2 more sources
Complementizer Drop And IP Complementation in Japanese
, 2000 The main purpose of the present paper is to provide a principled account for a phenomenon called "Complementizer Drop" in the dialects of Japanese and its related phenomena in teens of the head-raising approach without recourse to the ECP or GB-type ...
Fukuda, Minoru
core +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Complementizer Deletion in Spanish [PDF]
Complementizer Deletion (CD) in Spanish is allowed with an emotional selecting verb and an irrealis embedded verb. No XPs can occupy the preverbal embedded position.
Facchin, Clarissa
core +1 more source
Complementizer Distribution in Sinhala [PDF]
, 2019 The extensive amount of empirical studies and consequent theorizing associated with the complementizer show the prominence attached to this functional category over the last few decades.
Ananda, M.G.L.
core +1 more source