Results 91 to 100 of about 10,963 (227)

Meta-analysis of Androgen Insensitivity in Preoperative Hormone Therapy in Hypospadias. [PDF]

, 2015
OBJECTIVE: To define androgen insensitivity prevalence in hypospadias patients treated with preoperative hormone therapy. MATERIALS AND METHODS: We searched databases that were published in English and Chinese up to September 10, 2014 for our studies ...
Ahmed, Chalapathi, Davits, Fievet, Gearhart, Gilliver, Gorduza, Grino, Hughes, Hughes, Ishii, Ji-Liang Li, Jianchun Yin, Jinjin Xie, Jones, Kalfa, Kaya, Koff, Li, Luo, Malik, McPhaul, Monfort, Nerli, Netto, Sakakibara, Shih, Snodgrass, Sterne, Tsur, Wang, Wanhua Xu, Weiguang Zhao, Wright, Yingtian Zhang, Zhang, Zhilin Yang   +36 more
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Complete androgen insensitivity syndrome

Medicinski vjesnik, 2007
Sindrom potpune neosjetljivosti na anđrogene otkriva se u djevojčica adolescentne dobi s izostankom menarhe ili djevojčica mlađe dobi s ingvinalnom hernijom. Ginekološki nalaz otkriva izostanak razvoja struktura koje nastaju od Miillerovih kanala (maternice, jajovoda i gornjega dijela vagine).
Wagner, Jasenka, Škrlec, Ivana, Štibi, Sanela, Viljetić, Barbara, Pušeljić, Silvija, Stipoljev, Feodora, Heffer-Lauc, Marija   +6 more
openaire   +1 more source

Pre-germ cell neoplasia in-situ in a patient with complete androgen insensitivity syndrome

American Journal of Clinical Pathology, 2023
Complete androgen insensitivity syndrome is a disorder of sex development in 46, XY individuals with external female genitalia and undescended testes, often presenting with inguinal hernia in infancy and/or primary amenorrhea in adolescents.
J. Muldoon, K. Collins, T. Ulbright, I. A. González   +3 more
semanticscholar   +1 more source

Extracellular Vesicles Released From Prostate Cancer Cells Confer Pro‐Tumor Properties to Adipocytes by Stimulating Lipolysis

BioFactors, Volume 51, Issue 6, November/December 2025.
Extracellular vesicles (EVs) from prostate cancer (PCa) cells induce the release of fatty acids (FFAs) from adipocytes, which in turn sustain tumor cell proliferation and migration via Akt activation. ABSTRACT There is consistent evidence of an association between obesity and the risk of prostate cancer (PCa). A crosstalk between PCa and adipocytes has
Gaia Giannitti, Kinga Kamińska, Sara Marchesi, Riccardo Garavaglia, Ivan Preosto, Małgorzata Grzesiak, Fabrizio Fontana   +6 more
wiley   +1 more source

Complete androgen insensitivity syndrome, a pedigree gene mutation analysis [PDF]

, 2016
研究背景 雄激素不敏感综合征（AndrogenInsensitivitySyndrome，AIS），是一种常见的男性假两性畸形。是伴X连锁隐性遗传病。患者染色体核型为46，XY，但其X染色体上的雄激素受体（Androgenreceptor，AR）基因存在缺陷，可致雄激素靶器官上的AR出现缺陷，体内的雄激素不能发挥相应的作用而出现相应的临床症状。此疾病可对患者的生殖能力造成不同程度的影响，还可能引发与性发育异常相关的性心理、性行为的异常，并可能给社会和患者家庭造成难以挽回的损失 ...
杨瑞娟
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Elevating and empowering reproductive futures: Pediatric and adolescent gynecology's specialized care across the globe

International Journal of Gynecology &Obstetrics, Volume 171, Issue 2, Page 528-537, November 2025.
Abstract Pediatric and adolescent gynecology (PAG) is an expanding subspecialty of obstetrics and gynecology that addresses the reproductive health needs of girls and young women worldwide. In regions with limited subspecialist healthcare providers, general obstetricians, gynecologists, and nurse‐midwives, frontline healthcare providers provide ...
Nichole A. Tyson, Méabh Ní Bhuinneáin, Hema Divakar, Lauren Mauger, Judith Simms Cendan, Marisa Labovsky, FIGO Committee on Adolescent and Youth Health   +6 more
wiley   +1 more source

Complete Androgen Insensitivity Syndrome.

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, 2008
The incidence of Complete Androgen Insensitivity Syndrome (CAIS) is about 1 in 20,000. People with CAIS are normal appearing females, despite the presence of testes and a 46, XY chromosome constitution. We came across a case in which a 17 years old girl presented with the complaint of inguinal hernia and amenorrhea.
Asra, Hashmi, Farha, Hanif, Shumaila Muhammad, Hanif, Farhan Essa, Abdullah, Muhammad Shahid, Shamim   +4 more
openaire   +1 more source

Protein Kinase C Family: Structures, Biological Functions, Diseases, and Pharmaceutical Interventions

MedComm, Volume 6, Issue 11, November 2025.
Ligand–receptor binding activates PLC, which hydrolyzes the membrane lipid PIP2, generating the second messenger's IP3 and DAG. IP3 binding to ER receptors causes Ca2⁺ release. Subsequently, PKC are recruited to the membrane, which induces a conformational change in PKC, leading to the full enzymatic activation.
Yongqi Li, Yuhan Jiang, Zhengxi Hu, Shenglan Yang, Longyin Li, Chaohu Xiong, Ya Gao, Weiguang Sun, Yonghui Zhang   +8 more
wiley   +1 more source

Epigenetic Clock Analysis of Sex Chromosome Aneuploidies

Aging Cell, Volume 24, Issue 11, November 2025.
Next‐generation epigenetic clocks indicate lower age acceleration and slower pace of aging in 47,XXY than 46,XX, 46,XY, and 47,XYY. A first‐generation clock (Skin & Blood) indicates higher age acceleration in 47,XXY and 47,XYY than 46,XY, while higher naïve CD8+ T in 47,XXY than both 46,XY and 46,XX suggests reduced immunosenescence.
Joshua Zhang, Jordan Teoli, Benjamin Rey, Cristina Vieira, Jean‐François Lemaitre, Ingrid Plotton, Gabriel A. B. Marais, Steve Horvath   +7 more
wiley   +1 more source

Disorders of sex development (DSD): an overview of recent scientific advances [PDF]

, 2014
Developments in biotechnology have radically altered clinical and research themes in the small field of disorders of sex development, as in other rare medical conditions. In the age of genetics, an increasing number of DSDs have been identified. Aided by
Conway, GS
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