Results 71 to 80 of about 13,631,201 (250)

Forecasting the Dialysis Burden in Japan: Validation‐Based Projections of Prevalence and Incidence Through 2050

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Japan has one of the highest dialysis prevalence rates worldwide and a shrinking, aging population. Whether dialysis burden has entered a sustained post‐peak phase or whether recent declines partly reflect pandemic‐related disruptions remains uncertain.
Hatice Şahin, Berrak Itır Aylı, Nüket Paksoy   +2 more
wiley   +1 more source

Risk factors of pathologic complete response for neoadjuvant chemoradiotherapy in locally advanced rectal cancer

Frontiers in Oncology
BackgroundGlobal cancer statistics indicate colorectal cancer as the second leading cause of cancer-related deaths, with rectal cancer accounting for approximately 30% of cases.
Liangjing Zhou, Gaoyang Cao, Liming Shi, Chunrong Fei, Weifeng Lao   +4 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Immunotherapy-Induced Complete Response in dMMR Rectal Cancer—A Surgical Dilemma?

Background: Deficient mismatch repair rectal cancer represents approximately 10% of rectal malignancies and demonstrates exceptional responsiveness to immune checkpoint inhibitors, achieving unprecedented complete response rates approaching 100%.
Frountzas, Maximos, Panagiotis Loufopoulos, Rasheed, Shahnawaz, Eddama, Mohammad Mahmoud Rajab, Maximos Frountzas, Perivoliotis, Konstantinos, Tekkis, Paris, Anisha Sukha, Paris Tekkis, Chatziathanasiou, Danai, Alrebdi, Abdullah, Qiu, Shengyang, Sukha, Anisha, Danai Chatziathanasiou, Loufopoulos, Panagiotis, Kontovounisios, Christos, Mohammad Mahmoud Rajab Eddama, Abdullah Alrebdi, Shengyang Qiu, Christos Kontovounisios, Konstantinos Perivoliotis, Shahnawaz Rasheed   +21 more
core   +1 more source

Total Neoadjuvant Therapy Versus Long-Course Chemoradiotherapy in Locally Advanced Rectal Cancer: Real-World Tumor Response and Clinical Outcomes

Medical Sciences
Background: Total neoadjuvant therapy is becoming a preferred option for locally advanced rectal cancer, particularly in patients with high-risk baseline features.
Sorinel Lunca, Wee Liam Ong, Stefan Morarasu, Ana Maria Musina, Cristian Ene Roata, Raluca Zaharia, Gabriel Mihail Dimofte   +6 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

The comparison of clinical and histopathologic findings according to the complete response to treatment.

, 2021
The comparison of clinical and histopathologic findings according to the complete response to treatment.
Elvina Almuradova (11663234), Merve Guner Oytun (11663231), Mustafa Harman (11663237), Ruchan Uslu (816262), Gulcan Bulut (11663228), Bulent Karabulut (11663240)   +5 more
core   +1 more source

Is surgery necessary for mismatch repair-deficient/microsatellite instability-high colorectal cancer patients with a clinical complete response after neoadjuvant immunotherapy? A retrospective cohort study with literature context

World Journal of Surgical Oncology
Background The purpose of this study was to retrospectively compare the prognostic outcomes of patients with colorectal cancer (CRC) who achieved a clinical complete response (CCR) after neoadjuvant immunotherapy (NI) and those who achieved a CCR after ...
Hongqun Zuo, Jian Huang, Shengquan Peng, Jie Wei, Yinxiang Luo, Shimeng Qin, Xiaojun Zou, Ju Rong, Yuan Lin, Hao Lai, Xianwei Mo   +10 more
doaj   +1 more source