Total Neoadjuvant Therapy Versus Long-Course Chemoradiotherapy in Locally Advanced Rectal Cancer: Real-World Tumor Response and Clinical Outcomes [PDF]
Medical SciencesBackground: Total neoadjuvant therapy is becoming a preferred option for locally advanced rectal cancer, particularly in patients with high-risk baseline features.
Sorinel Lunca +6 more
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Quality of life following total neoadjuvant therapy for rectal cancer [PDF]
Journal of Cancer Research and Clinical OncologyPurpose This study aimed to assess the health-related quality of life (HRQoL) in patients with locally advanced rectal cancer (LARC) undergoing total neoadjuvant therapy (TNT), comparing outcomes with the German general population and colorectal cancer ...
Georg W. Wurschi +15 more
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Pathological lymph node response after immunotherapy-based total neoadjuvant therapy supports local excision for organ preservation in locally advanced rectal cancer: a propensity-score weighted analysis [PDF]
Clinical and Translational Radiation OncologyBackground: The immunotherapy-based total neoadjuvant therapy (iTNT) has improved response rates in locally advanced rectal cancer (LARC); however, a majority of patients do not achieve clinical complete response (cCR) and still require total mesorectal ...
Shujuan Zhou +9 more
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Total neoadjuvant therapy for rectal cancer: evidence and challenge [PDF]
Annals of Coloproctology, 2023 Recent advances in the management of rectal cancer have dramatically changed the clinical practice of colorectal surgeons because the main focus of rectal cancer treatment has changed from sphincter-saving to an organ-preserving strategies. Modifying the
Suk-Hwan Lee
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Influence of neoadjuvant radiotherapy combined with immunotherapy on minimally invasive surgeries for rectal cancer [PDF]
Waike lilun yu shijian, 2023 The current domestic and international guidelines recommend neoadjuvant chemoradiation or total neoadjuvant therapy followed by radical surgery for mid-low locally advanced rectal cancer.
YANG Yingchi, PANG Kai, ZHANG Zhongtao
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Total neoadjuvant therapy in rectal cancer: a network meta-analysis of randomized trials [PDF]
Annals of Coloproctology, 2023 Purpose To assess the efficacy of total neoadjuvant therapy (TNT) for rectal carcinoma in comparison with conventional chemoradiotherapy (CRT). Methods A systematic review was performed according to the PRISMA guidelines. A Bayesian network meta-analysis
Sergey Sychev +7 more
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Indian Journal of Pathology and Microbiology, 2023 Background: The efficacy of neoadjuvant therapy for rectal cancer has not been assessed. Objective: To evaluate proportional changes in peripheral blood immune cells in rectal cancer patients after neoadjuvant therapy and assess the relationship between ...
Liu Maoxi, Liu Haiyi
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Frontiers in Surgery, 2022 Neoadjuvant therapy improves overall survival compared with a surgery-first approach in patients with borderline resectable pancreatic cancer (BRPC). Evidence of higher quality is required to determine whether neoadjuvant therapy has potential benefits ...
Knut Jørgen Labori, Knut Jørgen Labori
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Frontiers in Immunology, 2023 ObjectivesRecent clinical studies have demonstrated that immunotherapy-based neoadjuvant therapy have promising effectiveness for patients with resectable non-small cell lung cancer (NSCLC) in terms of pathologic response.
Jie Shen +5 more
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Neoadjuvant Four-Drug Combination Therapy for NSCLC With EGFR Mutation Avoiding Total Pneumonectomy
Frontiers in Oncology, 2020 We report a case of successful neoadjuvant four-drug combination therapy to avoid total pneumonectomy. A 33-year-old male patient was diagnosed with locally advanced non-squamous NSCLC harboring EGFR mutation in the left lower lobe.
Jingpei Li +24 more
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