Results 21 to 30 of about 8,795,233 (257)

Biomarker Alteration after Neoadjuvant Endocrine Therapy or Chemotherapy in Estrogen Receptor-Positive Breast Cancer

Life, 2022
In estrogen receptor (ER)-positive breast cancer, changes in biomarker expression after neoadjuvant therapy indicate the therapeutic response and are prognostic.
Mengping Long, Chong You, Qianqian Song, Lina X. J. Hu, Zhaorong Guo, Qian Yao, Wei Hou, Wei Sun, Baosheng Liang, Xiao-Hua Zhou, Yiqiang Liu, Taobo Hu   +11 more
doaj   +1 more source

Ifosfamide with regional hyperthermia in soft-tissue sarcomas [PDF]

, 2003
For high-risk soft tissue sarcomas (HR-STS) of adults, new treatment strategies are needed to improve outcome with regard to local control and overall survival.
M. Schlemmer, Wendtner, Clemens-Martin, C.M. Wendtner, R.D. Issels, Schlemmer, M., Issels, Rolf-Dieter   +5 more
core   +1 more source

New Pattern of Rectal Cancer Treatment: Total Neoadjuvant Therapy

Zhongliu Fangzhi Yanjiu, 2018
Total neoadjuvant therapy (TNT) transfers postoperative adjuvant chemotherapy for rectal cancer to preoperative surgery. Preoperative neoadjuvant chemotherapy followed by concurrent chemoradiotherapy is designed to improve patient compliance and long ...
SUN Peiyan, WU Gang, SUN Peichun
doaj   +1 more source

An exploratory study on the checkout rate of circulating tumor cells and the prediction of efficacy of neoadjuvant therapy and prognosis in patients with HER-2-positive early breast cancer

Frontiers in Oncology, 2022
BackgroundNeoadjuvant therapy is a standard treatment for patients with large, nonmetastatic breast cancer and may allow breast-conserving surgery after tumor downsizing while decreasing the risk of subsequent relapse.
Jinmei Zhou, Jiangling Wu, Jiangling Wu, Xiaopeng Hao, Ping Li, Huiqiang Zhang, Xuexue Wu, Jiaxin Chen, Jiawei Liu, Jinyi Xiao, Shaohua Zhang, Zefei Jiang, Yanlian Yang, Zhiyuan Hu, Zhiyuan Hu, Zhiyuan Hu, Zhiyuan Hu, Zhiyuan Hu, Tao Wang   +18 more
doaj   +1 more source

Trimodal Therapy in Esophageal Squamous Cell Carcinoma: Role of Adjuvant Therapy Following Neoadjuvant Chemoradiation and Surgery

, 2022
SIMPLE SUMMARY: In this work, we aimed to explore the effectiveness of adjuvant therapy after trimodal therapy (neoadjuvant chemoradiotherapy and esophagectomy) in patients with thoracic esophageal squamous cell carcinoma (ESCC).
Fang, Pinhao, Shang, Qixin, Xiao, Xin, Hanlu Zhang, Pinhao Fang, Yong Yuan, Luan, Siyuan, Xin Xiao, Xiaokun Li, Siyuan Luan, Yang, Yushang, Zhou, Jianfeng, Yushang Yang, Yuan, Yong, Jianfeng Zhou, Qixin Shang, Li, Xiaokun, Zhang, Hanlu   +17 more
core   +1 more source

Pyrotinib-Containing Neoadjuvant Therapy in Patients With HER2-Positive Breast Cancer: A Multicenter Retrospective Analysis

Frontiers in Oncology, 2022
BackgroundPyrotinib, a small-molecule tyrosine kinase inhibitor, has been investigated as a component of neoadjuvant therapy in phase 2 trials of human epidermal growth factor receptor 2 (HER2)-positive breast cancer.
Xiaoyun Mao, Pengwei Lv, Yiping Gong, Xiujuan Wu, Peng Tang, Shushu Wang, Dianlong Zhang, Wei You, Ouchen Wang, Jun Zhou, Jingruo Li, Feng Jin   +11 more
doaj   +1 more source

HER2 and ESR1 mRNA expression levels and response to neoadjuvant trastuzumab plus chemotherapy in patients with primary breast cancer [PDF]

, 2013
Introduction: Recent data suggest that benefit from trastuzumab and chemotherapy might be related to expression of HER2 and estrogen receptor (ESR1). Therefore, we investigated HER2 and ESR1 mRNA levels in core biopsies of HER2-positive breast carcinomas
Jens Huober, Reinisch, Mattea, Sibylle Loibl, Silvia Darb-Esfahani, Michael Untch, Hans Tesch, Martin-Leo Hansmann, Jan C Brase, Knut Engels, Judith Prinzler, Keyur Mehta, Minckwitz, Gunter von, Brase, Jan C., Kronenwett, Ralf, Hansmann, Martin-Leo, Huober, Jens, Engels, Knut, Solbach, Christine, Tesch, Hans, Carsten Denkert, Denkert, Carsten, Gunter von Minckwitz, Bruno V Sinn, Loibl, Sibylle, Mattea Reinisch, Peter A Fasching, Sinn, Bruno V., Ralf Kronenwett, Christine Solbach, Prinzler, Judith, Mehta, Keyur, Fasching, Peter Andreas, Untch, Michael, Denkert, Carsten Michael, Darb-Esfahani, Silvia   +34 more
core   +2 more sources

How We Treat Localized Rectal Cancer—An Institutional Paradigm for Total Neoadjuvant Therapy

, 2022
Total neoadjuvant therapy (TNT)—the neoadjuvant employment of radiotherapy (RT) or chemoradiation (CRT) as well as chemotherapy (CHT) before surgery—may lead to increased pathological complete response (pCR) rates as well as a reduction in ...
Florian Huemer, Klieser, Eckhard, Jäger, Tarkan, Eckhard Klieser, Sedlmayer, Felix, Weiss, Lukas, Greil, Richard, Stefan Hecht, Tarkan Jäger, Kaufmann, Reinhard, Hecht, Stefan, Felix Sedlmayer, Emmanuel, Klaus, Sabine Gerum, Oliver Owen Koch, Huemer, Florian, Klaus Emmanuel, Roeder, Falk, Richard Greil, Lukas Weiss, Reinhard Kaufmann, Falk Roeder, Daniel Neureiter, Gerum, Sabine, Neureiter, Daniel, Koch, Oliver Owen   +25 more
core   +1 more source

Skeletal Muscle Change During Neoadjuvant Therapy and Its Impact on Prognosis in Patients With Gastrointestinal Cancers: A Systematic Review and Meta-Analysis

Frontiers in Oncology, 2022
BackgroundGastrointestinal cancers are the most common malignant tumors worldwide. As the improvement of survival by surgical resection alone for cancers is close to the bottleneck, recent neoadjuvant therapy has been emphasized and applied in the ...
Xin-Yi Xu, Xiao-Man Jiang, Qin Xu, Hao Xu, Jin-Hua Luo, Cui Yao, Ling-Yu Ding, Shu-Qin Zhu   +7 more
doaj   +1 more source

Impact of body mass index in therapeutic response for HER2 positive breast cancer treated with neoadjuvant targeted therapy: a multi-center study and meta-analysis

npj Breast Cancer, 2023
While overweight/obesity has become a major public health issue worldwide, any association between body mass index (BMI) and therapeutic response in neoadjuvant targeted therapy treated HER2 positive breast cancer patients remain unclear. The information
Lili Chen, Fan Wu, Xiaobin Chen, Yazhen Chen, Lin Deng, Qindong Cai, Long Wu, Wenhui Guo, Minyan Chen, Yan Li, Wenzhe Zhang, Xuan Jin, Hanxi Chen, Qian Nie, Xiong Wu, Yuxiang Lin, Chuan Wang, Fangmeng Fu   +17 more
doaj   +1 more source