Results 41 to 50 of about 8,795,233 (257)

Clinical Impact of Total Neoadjuvant Therapy Combined with Dose-Escalated Intensity-Modulated Radiotherapy for Lower Rectal Cancer: A Comparison with Conventional Neoadjuvant Chemoradiotherapy. [PDF]

Cancers (Basel)
Background: This study aimed to compare the outcomes and safety profiles of total neoadjuvant therapy (TNT) combined with dose-escalated intensity-modulated radiotherapy (IMRT) and conventional neoadjuvant chemoradiotherapy (NACRT) using three ...
Kawamura M, Toyomasu Y, Yamashita S, Ieki H, Imaoka H, Shimura T, Kitajima T, Okugawa Y, Okita Y, Ohi M, Nomoto Y, Toiyama Y.   +11 more
europepmc   +2 more sources

Ovarian Sex Cord Stromal Tumors in Children and Adolescents—The European Standard Clinical Practice Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT As part of the European Cooperative Study Group for Paediatric Rare Tumours initiative, we developed standard clinical practice guidelines for ovarian sex cord stromal tumors, based on comprehensive national and international cohort analyses, literature review, and a final expert consensus conference.
Dominik T. Schneider, Kris‐Ann Schultz, Nora Schnitzler, Michael Abele, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Ines B. Brecht, Maja Cesen, Andrea Ferrari, Michaela Kuhlen, Malgorzata A. Krawczyk, Ricardo Lopez‐Almaraz, Yves Reguerre, Calogero Virgone, Daniel Orbach   +15 more
wiley   +1 more source

Neoadjuvant Multikinase Inhibitor in Patients With Locally Advanced Unresectable Thyroid Carcinoma

Frontiers in Endocrinology, 2019
Background: Papillary thyroid carcinoma (PTC) is the most common and less aggressive thyroid cancer, but some patients may display locally advanced disease. Therapeutic options are limited in these cases, particularly for those patients with unresectable
Carla Fernanda Nava, Rafael Selbach Scheffel, Ana Patrícia Cristo, Carla Vaz Ferreira, Shana Weber, André Borsatto Zanella, Francisco Costa Paixão, Alceu Migliavaca, José Ricardo Guimarães, Marcia Silveira Graudenz, José Miguel Dora, Ana Luiza Maia   +11 more
doaj   +1 more source

Total Neoadjuvant Therapy in Locally Advanced Rectal Cancer: A Systematic Review and Metaanalysis of Oncological and Operative Outcomes [PDF]

, 2021
Background: Total neoadjuvant therapy in rectal cancer refers to the administration of chemoradiotherapy plus chemotherapy before surgery. Recent studies have shown improved pathological complete response and disease-free survival with this approach ...
Leong, Trevor, Michael, Michael, Soucisse, Mikael, McCormick, Jacob, Kong, Joseph C, Tie, Jeanne, Ngan, Samuel Y, Heriot, Alexander G, Warrier, Satish K, Sica, G   +9 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

RETRACTED ARTICLE: Effect of neoadjuvant chemotherapy combined with arterial chemoembolization on short-term clinical outcome of locally advanced gastric cancer

BMC Cancer, 2023
Background The purpose of this study was to explore the short-term efficacy and safety of neoadjuvant chemotherapy combined with arterial chemoembolization for locally advanced gastric cancer (LAGC).
Jianguo Yang, Juncai Li, Qican Deng, Zhenzhou Chen, Kuan He, Yajun Chen, Zhongxue Fu   +6 more
doaj   +1 more source

Radiotherapy in the preoperative neoadjuvant treatment of locally advanced rectal cancer

Frontiers in Oncology, 2023
Radiotherapy and chemotherapy are effective treatments for patients with locally advanced rectal cancer (LARC) and can significantly improve the likelihood of R0 resection.
Zhen Yu, Yuying Hao, Yuhua Huang, Ling Ling, Xigang Hu, Simiao Qiao   +5 more
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Total neoadjuvant therapy for locally advanced gastric cancer and esophagogastric junction adenocarcinoma: study protocol for a prospective, multicenter, single-arm, phase II clinical trial

BMC Gastroenterology, 2022
Background Gastric cancer ranks high in terms of morbidity and mortality worldwide. Multimodal therapy is therefore essential for locally advanced gastric cancer.
Jinming Shi, Ning Li, Yuan Tang, Liming Jiang, Lin Yang, Shulian Wang, Yongwen Song, Yueping Liu, Hui Fang, Ningning Lu, Shunan Qi, Bo Chen, Ziyu Li, Shixin Liu, Jun Wang, Wenling Wang, Suyu Zhu, Jialin Yang, Yexiong Li, Dongbing Zhao, Jing Jin   +20 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source