Results 51 to 60 of about 8,795,233 (257)

Prognostic value of tumor deposits and their different response to neoadjuvant therapy in locally advanced rectal cancer.

PLoS ONE
BackgroundTumor deposits (TDs) may have a worse prognosis in rectal cancer, but their significance in the neoadjuvant era is less certain. Post-treatment TDs might even be a sign of tumor response.
Di Zhou, Junjun Zhou, Bin Hu, Yinjue Yu, Yuhai Bian, Cuiping Yang, Yongrui Bai, Haiyan Chen   +7 more
doaj   +1 more source

Neoadjuvant Therapy in Locally Advanced Rectal Cancer—What Result Should We Expect?

Medicina
Background and Objectives: Neoadjuvant chemoradiotherapy is a key component of the treatment strategy for locally advanced rectal cancer (LARC), both through its direct impact on oncological prognosis and by increasing the likelihood of sphincter ...
Roxana-Elena Stefan, Adrian Constantin, Daniela Dinu, Florin Achim, Alexandru Rotariu, Florin Grama, Horia-Dan Liscu, Lucian Iordache, Dragos-Viorel Scripcariu, Anthony Rasuceanu, Silviu Constantinoiu, Dragos Predescu   +11 more
doaj   +1 more source

IDO1 Expression Increased After Neoadjuvant Therapy Predicts Poor Pathologic Response and Prognosis in Esophageal Squamous Cell Carcinoma

Frontiers in Oncology, 2020
Indoleamine 2,3-dioxygenase (IDO1) plays an important role in tumor immune evasion. In this study, we investigated the changes of tumor IDO1 expression and CD8+ tumor-infiltrating lymphocytes (TILs) status in tumor microenvironment (TME) after ...
Ruidi Jiao, Xiaoli Zheng, Yanan Sun, Zhuo Feng, Shuai Song, Hong Ge   +5 more
doaj   +1 more source

Axillary Downstaging and the Impact of Clinical Axillary Status on Efficacy of Neoadjuvant Therapy for HER2-Positive Breast Cancer: A Network Meta-Analysis

Technology in Cancer Research & Treatment, 2023
Background: Lymph node downstaging and the achievement of total-pCR (ypT0/is ypN0) after neoadjuvant therapy are of great importance in HER-2 positive breast cancer.
Yunzhao Luo MM, Hongchuan Jiang MB, Chengjiang Liu MD, Chao Zhang MM   +3 more
doaj   +1 more source

Tailored total neoadjuvant therapy for locally advanced rectal cancer: One size may not fit for all!

, 2021
While current neoadjuvant protocols have proven benefits on local control for majority of patients with locally advanced rectal cancer, there are certain clinical conditions that require future advances for improving the outcomes.
Yildiz, Ibrahim, Feza H. Remzi, Ibrahim Yildiz, Eren Esen, Esen, Eren, Leyla Ozer, Mustafa Bozkurt, Erman Aytac, Vedat Bayoglu, Gogenur, Ismail, Ozer, Leyla, Ismail Gogenur, Remzi, Feza H., Aytac, Erman, Bayoglu, Vedat, Bozkurt, Mustafa   +15 more
core   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

Supersensitive PSA-Monitored neoadjuvant hormone treatment of clinically localized prostate cancer: Effects on positive margins, tumor detection and epithelial cells in bone marrow [PDF]

, 1998
Objective: The present study was done to investigate the effects of supersensitive PSA-controlled inductive treatment on positive margins, detection of tumor and epithelial cells in bone marrow of 101 patients with untreated and clinically localized ...
Köllermann, J., Kaulfuss, U., Spitz, J., Enzmann, Th., Köllermann M. W., Feek, U., Martell, W., Kossiwakis, M.   +7 more
core   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Deciphering the Dilemma: Choosing the Optimal Total Neoadjuvant Treatment Strategy for Locally Advanced Rectal Cancer

Current Oncology
Rectal cancer management has evolved significantly, particularly with neoadjuvant treatment strategies. This narrative review examines the development and effectiveness of these therapies for locally advanced rectal cancer (LARC), highlighting the ...
Erik Manriquez, Sebastián Solé, Javiera Silva, Juan Pablo Hermosilla, Rubén Romero, Felipe Quezada-Diaz   +5 more
doaj   +1 more source

Clinicopathological features, clinical efficacy on 101 cases of rectal gastrointestinal stromal tumors, and the significance of neoadjuvant therapy

BMC Surgery, 2021
Objective To investigate the clinicopathological features and clinical efficacy among 101 cases of rectal gastrointestinal stromal tumors (GISTs) and to investigate the significance of imatinib mesylate (IM) neoadjuvant therapy.
Hongxin Yang, Chaoyong Shen, Xiaonan Yin, Zhaolun Cai, Qian Wang, Bo Zhang   +5 more
doaj   +1 more source