Results 81 to 90 of about 13,631,201 (250)

Clinical factors of post-chemoradiotherapy as valuable indicators for pathological complete response in locally advanced rectal cancer

Clinics
OBJECTIVES: Pathological complete response has shown a better prognosis for patients with locally advanced rectal cancer after preoperative chemoradiotherapy.
Jianhong Peng, Junzhong Lin, Miaozhen Qiu, Xiaojun Wu, Zhenhai Lu, Gong Chen, Liren Li, Peirong Ding, Yuanhong Gao, Zhifan Zeng, Huizhong Zhang, Desen Wan, Zhizhong Pan   +12 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Clinical Complete Response and Organ Preservation Strategies in Rectal Cancer: A Real-World Single-Center Experience Clinical Complete Response and Organ Preservation in Rectal Cancer

Background: The management of rectal cancer has evolved toward response-adapted strategies, including organ preservation in selected patients achieving a clinical complete response (cCR) after neoadjuvant treatment.
Ruiz Carreño, Paula, Marín Vera, Miguel, I. Abellán, M. Montoya, M. Sánchez, Y. Bautista, J.A. Nadal, G. Carbonell, N. Ibáñez, Abrisqueta Carrión, Jesús, L. Frutos, E. Ortiz, C. Manso, Royo-Villanova Reparaz, Carlota, J.A. Encarnación, I. de la Fuente, C. Rodríguez, Quiles, B., S. González, Alonso Romero, José Luis, A. Ono   +20 more
core   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Deep learning analysis of MRI to assess rectal cancer treatment

Frontiers in Oncology
IntroductionTraditional neoadjuvant therapy for locally advanced rectal cancer (LARC) results in pathologic complete response (pCR) in approximately 15% of patients, supporting non-operative strategies for those with clinical complete response (cCR). The
Heather M. Selby, Ashley Y. Son, Vipul R. Sheth, Todd H. Wagner, Todd H. Wagner, Erqi L. Pollom, Arden M. Morris   +6 more
doaj   +1 more source

Clinical predictive factors associated with pathologic complete response in locally advanced rectal cancer

Journal of Oncological Sciences, 2018
Objective: In this study, our aim was to identify the main predictive factors associated with pathologic complete response (pCR) to neoadjuvantchemoradiotherapy (nCRT) in patients with locally advanced rectal cancer. Methods: The patients who had locally
Yakup Bozkaya, Nuriye Yıldırım Özdemir, Gökmen Umut Erdem, Ebru Karcı Güner, Yüksel Ürün, Nebi Serkan Demirci, Ozan Yazıcı, Osman Köstek, Nurullah Zengin   +8 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Complete remission of advanced MSI-H rectal cancer in a young patient treated with nivolumab: a case report and critical appraisal of the literature

Frontiers in Oncology
Colorectal cancer is a heterogeneous disease, where therapy is chosen based on the presence or absence of predictive and prognostic markers, leading to a higher degree of treatment individualization with the aim of maximizing clinical benefit. In general,
Marian Liberko, Marian Liberko, Renata Soumarova, Renata Soumarova   +3 more
doaj   +1 more source