Results 41 to 50 of about 169,110 (303)

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

A generalization of the global limit theorems of R. P. Agnew

International Journal of Mathematics and Mathematical Sciences, 1988
For distribution functions {Fn,n≥0}, the relationship between the weak convergence of Fn to F0 and the convergence of ∫Rϕ(|Fn−F0|)dx to 0 is studied where ϕ is a nonnegative, nondecreasing function.
Andrew Rosalsky
doaj   +1 more source

Complete convergence and complete moment convergence for extended negatively dependent random variables

Filomat, 2017
In this paper, we provide some probability and moment inequalities (especially the Marcinkiewicz-Zygmund type inequality) for extended negatively dependent (END, in short) random variables. By using the Marcinkiewicz-Zygmund type inequality and the truncation method, we investigate the complete convergence for sums and weighted sums of ...
Shen, Aiting, Zhang, Yu, Wang, Wenjuan
openaire   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Complete convergence and complete integration convergence for weighted sums of arrays of rowwise m-END under sub-linear expectations space

AIMS Mathematics, 2023
In this paper, we study the complete convergence and the complete integration convergence for weighted sums of $ m $-extended negatively dependent ($ m $-END) random variables under sub-linear expectations space with the condition of $ \hat{\mathbb{E}}|X|
He Dong, Xili Tan, Yong Zhang
doaj   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Sufficient and necessary conditions of convergence for ρ͠ mixing random variables

Open Mathematics, 2019
In the present paper, the sufficient and necessary conditions of the complete convergence and complete moment convergence for ρ͠-mixing random variables are established, which extend some well-known results.
Zhang Shui-Li, Miao Yu, Qu Cong
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Complete convergence and complete moment convergence for maximal weighted sums of extended negatively dependent random variables under sub-linear expectations

AIMS Mathematics, 2023
In this article, we study the complete convergence and complete moment convergence for maximal weighted sums of extended negatively dependent random variables under sub-linear expectations.
Mingzhou Xu
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source