Structure‐forward targeting of claudins with synthetic binders
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Complete genome sequence of Rhizobium leguminosarum bv trifolii strain WSM2304, an effective microsymbiont of the South American clover Trifolium polymorphum. [PDF]
Rhizobium leguminosarum bv trifolii is the effective nitrogen fixing microsymbiont of a diverse range of annual and perennial Trifolium (clover) species.
Alex Copeland +68 more
core +1 more source
The complete chloroplast genome sequence of Vitis hancockii
In this study, the complete chloroplast genome of Vitis hancockii was assembled for the first time. This genome was 161,205 bp in length, containing a large single copy region (89,397 bp) and a small single copy region (19,100 bp), seperated by two ...
Peining Fu +5 more
doaj +1 more source
Complete chloroplast genome sequence of Epimedium dewuense (Berberidaceae)
Epimedium dewuense S. Z. He is a rare and endangered endemic to China. The complete chloroplast (cp) genome of E. dewuense was reported in this study.
Fulin Yan +4 more
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Complete genome sequence, lifestyle, and multi-drug resistance of the human pathogen Corynebacterium resistens DSM 45100 isolated from blood samples of a leukemia patient [PDF]
Schröder J, Maus I, Meyer K, et al. Complete genome sequence, lifestyle, and multi-drug resistance of the human pathogen Corynebacterium resistens DSM 45100 isolated from blood samples of a leukemia patient. BMC Genomics.
Jochen Blom +27 more
core +1 more source
Epigenetic reprogramming of lineage switching in cancer
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Optical mapping as a routine tool for bacterial genome sequence finishing [PDF]
Background: In sequencing the genomes of two Xenorhabdus species, we encountered a large number of sequence repeats and assembly anomalies that stalled finishing efforts.
Norton, S. +57 more
core +1 more source
The complete chloroplast genome sequence of Canarium album
The first complete chloroplast genome (cpDNA) sequence of Canarium album was determined from Illumina HiSeq pair-end sequencing data in this study. The cpDNA is 163,347 bp in length, contains a large single-copy (LSC) region of 87,838 bp and a small ...
Yi Wang, Jiabo Hao, Bin Lu
doaj +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source

