Results 111 to 120 of about 397,867 (315)

The photoswitchable cannabinoid azo‐HU308 enables optical control of Ca2+ dynamics in INS‐1 β‐cells via off‐target effects on TRPC channels

open access: yesFEBS Open Bio, EarlyView.
Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley   +1 more source

Determining the b-chromatic number of subdivision-vertex neighbourhood coronas

open access: yesAnalele Stiintifice ale Universitatii Ovidius Constanta: Seria Matematica
Let G and H be two graphs, each one of them being a path, a cycle or a star. In this paper, we determine the b-chromatic number of every subdivision-vertex neighbourhood corona G ⊡ H or G ⊡ Kn, where Kn is the complete graph of order n.
Falcón Raúl M.   +2 more
doaj   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

open access: yesFEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid   +3 more
wiley   +1 more source

Temporal Ramsey Graphs: The Ramsey Kinematic Approach to the Motion of Systems of Material Points

open access: yesDynamics
The Ramsey approach is applied to analyses of the kinematics of systems built of non-relativistic, motile point masses/particles. This approach is based on colored graph theory. Point masses/particles serve as the vertices of the graph.
Edward Bormashenko
doaj   +1 more source

Complete Fuzzy Graphs

open access: yes, 2011
In this paper, we provide three new operations on fuzzy graphs; namely direct product, semi-strong product and strong product.We give sufficient conditions for each one of them to be complete and we show that if any of these products is complete, then at least one factor is a complete fuzzy graph. Moreover, we introduce and study the notion of balanced
openaire   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

open access: yesFEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava   +3 more
wiley   +1 more source

Simulations for the Susceptible-Exposed-Infected-Recovered (SEIR) Model in the Forecast of Epidemic Outbreak

open access: yesJournal of Engineering Technology and Applied Physics
Mathematical modelling based on the compartmental Susceptible – Exposed – Infected - Recovered (SEIR) model is proposed in this paper to study the pandemic outbreak.
Mei Feng Liu, Boo Hui Ling
doaj   +1 more source

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