Results 91 to 100 of about 423,962 (267)
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Efficient Circuit Implementations of Continuous-Time Quantum Walks for Quantum Search
EntropyQuantum walks are a powerful framework for simulating complex quantum systems and designing quantum algorithms, particularly for spatial search on graphs, where the goal is to find a marked vertex efficiently.
Renato Portugal, Jalil Khatibi Moqadam
doaj +1 more source
Completely connected clustered graphs
Journal of Discrete Algorithms, 2003 A clustered graph \((G,T,r)\) consists of a graph \(G=(V,E)\), a tree \(T\), and an inner vertex \(r\) of \(T\) such that the set of leaves of \(T\) is exactly \(V\). A clustered graph is said to be completely connected if every cluster, and also each complement of a cluster, induces a connected subgraph.
Sabine Cornelsen, Dorothea Wagner
openaire +2 more sources
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
IEEE Access, 2018 In this paper, we have proposed altogether different and new approaches for the computation of all possible spanning trees of a simple, undirected, and connected graph.
Maumita Chakraborty +2 more
doaj +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Long Paths in First Passage Percolation on the Complete Graph II. Global Branching Dynamics. [PDF]
J Stat Phys, 2020 Eckhoff M +3 more
europepmc +1 more source
Discrete Mathematics, 2006 Let \(S= (S_1,\dots, S_n)\) be an out-degree vector of an orientation of a graph \(G\) with vertices \(1,\dots, n\). According to the partial order \(\succeq\) on the nonnegative integral vectors [see \textit{H. J. Ryser}, J. Algebra 10, 246--261 (1968; Zbl 0167.28001)] \(S^r_G\succeq S\succeq S^l_G\), \(\sum^n_{i=1} s_i= |E(G)|\) and \(0\leq s_i\leq ...
openaire +3 more sources