Results 71 to 80 of about 423,962 (267)
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Decompositions of Complete Multipartite Graphs into Complete Graphs
, 2011 Let $k\geq\ell\geq1$ and $n\geq 1$ be integers. Let $G(k,n)$ be the complete $k$-partite graph with $n$ vertices in each colour class. An $\ell$-decomposition of $G(k,n)$ is a set $X$ of copies of $K_k$ in $G(k,n)$ such that each copy of $K_\ell$ in $G(k,n)$ is a subgraph of exactly one copy of $K_k$ in $X$. This paper asks: when does $G(k,n)$ have an $
Fabila-Monroy, Ruy, Wood, David R.
openaire +2 more sources
Partitioning graphs into complete and empty graphs
Discrete Mathematics, 2009 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Tínaz Ekim, John Gimbel
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Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
A complete graph-based approach with multi-task learning for predicting synergistic drug combinations. [PDF]
Bioinformatics, 2023 Wang X +5 more
europepmc +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Consensus-Related Performance of Triplex MASs Based on Partial Complete Graph Structure. [PDF]
Entropy (Basel), 2022 Bian J, Huang D, Xu J, Yu Z.
europepmc +1 more source
Complete graph immersions in dense graphs [PDF]
Discrete Mathematics, 2017 In this article we consider the relationship between vertex coloring and the immersion order. Specifically, a conjecture proposed by Abu-Khzam and Langston in 2003, which says that the complete graph with $t$ vertices can be immersed in any $t$-chromatic graph, is studied.
openaire +3 more sources
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source