Results 111 to 120 of about 1,691,893 (274)

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

open access: yesFEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava   +3 more
wiley   +1 more source

Some Properties of the Nil-Graphs of Ideals of Commutative Rings

open access: yesپژوهش‌های ریاضی, 2022
Let R be a commutative ring with identity and Nil(R) be the set of nilpotent elements of R. The nil-graph of ideals of R is defined as the graph AG_N(R) whose vertex set is {I:(0)and there exists a non-trivial ideal  such that  and two distinct vertices  
Reza Nikandish
doaj  

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

open access: yesFEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies   +3 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

Landauer Principle and Einstein Synchronization of Clocks: Ramsey Approach

open access: yesEntropy
We introduce a synchronization procedure for clocks based on the Einstein–Landauer framework. Clocks are modeled as discrete, macroscopic devices operating at a thermal equilibrium temperature T.
Edward Bormashenko, Michael Nosonovsky
doaj   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

open access: yesFEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon   +6 more
wiley   +1 more source

Efficient Circuit Implementations of Continuous-Time Quantum Walks for Quantum Search

open access: yesEntropy
Quantum walks are a powerful framework for simulating complex quantum systems and designing quantum algorithms, particularly for spatial search on graphs, where the goal is to find a marked vertex efficiently.
Renato Portugal, Jalil Khatibi Moqadam
doaj   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

open access: yesFEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li   +8 more
wiley   +1 more source

Complete Fuzzy Graphs

open access: yes, 2011
In this paper, we provide three new operations on fuzzy graphs; namely direct product, semi-strong product and strong product.We give sufficient conditions for each one of them to be complete and we show that if any of these products is complete, then at least one factor is a complete fuzzy graph. Moreover, we introduce and study the notion of balanced
openaire   +1 more source

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