Results 41 to 50 of about 877,501 (328)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

First steps with Bott formula

Atti della Accademia Peloritana dei Pericolanti : Classe di Scienze Fisiche, Matematiche e Naturali, 2023
We use Bott's residue formula to infer that a general cubic surface in the projective space P^3_C contains exactly twenty seven lines and that a general complete intersection of two quadrics in P^4_C contains exactly sixteen lines.
Mustapha Lahyane, Israel Moreno-Mejía, Dan Silva-López   +2 more
doaj   +1 more source

Frobenius powers of complete intersections [PDF]

Mathematical Research Letters, 2001
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Avramov, Luchezar L., Miller, Claudia
openaire   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

5d SCFTs from isolated complete intersection singularities

Journal of High Energy Physics
In this paper, we explore the zoo of 5d superconformal field theories (SCFTs) constructed from M-theory on Isolated Complete Intersection Singularities (ICIS).
Jisheng Mu, Yi-Nan Wang, Hao N. Zhang
doaj   +1 more source

Mechanical Properties of Rock With Intersection Structures and its Progressive Failure Mechanism

IEEE Access, 2019
To investigate the influence of intersection structures on the mechanical properties and failure mechanisms of rock materials, a series of uniaxial compression tests on complete red sandstone specimens and specimens with various hole shapes (T-shape ...
Shaowei Ma, Zhouquan Luo, Hao Wu, Yaguang Qin   +3 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

On Constructing Constrained Tree Automata Recognizing Ground Instances of Constrained Terms [PDF]

Electronic Proceedings in Theoretical Computer Science, 2013
An inductive theorem proving method for constrained term rewriting systems, which is based on rewriting induction, needs a decision procedure for reduction-completeness of constrained terms.
Naoki Nishida, Masahiko Sakai, Yasuhiro Nakano   +2 more
doaj   +1 more source

Discrete Symmetries of Complete Intersection Calabi-Yau Manifolds

, 2017
In this paper, we classify non-freely acting discrete symmetries of complete intersection Calabi- Yau manifolds and their quotients by freely-acting symmetries.
Lukas, Andre, Mishra, Challenger
core   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source