Results 71 to 80 of about 828,524 (283)
On the completeness of metric spaces with a \(w\)-distance [PDF]
, 2020 Aleksandar Kostić
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Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
A Mizoguchi–Takahashi Type Fixed Point Theorem in Complete Extended b-Metric Spaces
Mathematics, 2019 In this paper, we prove a new fixed point theorem for a multi-valued mapping from a complete extended b-metric space U into the non empty closed and bounded subsets of U, which generalizes Nadler’s fixed point theorem.
Nayab Alamgir +3 more
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Rigidity for the logarithmic Sobolev inequality on complete metric measure spaces [PDF]
, 2023 Franciele Conrado
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On positive scalar curvature and moduli of curves
, 2018 In this article we first show that any finite cover of the moduli space of closed Riemann surfaces of genus $g$ with $g\geq 2$ does not admit any Riemannian metric $ds^2$ of nonnegative scalar curvature such that $ds^2 \succ ds_{T}^2$ where $ds_{T}^2$ is
Liu, Kefeng, Wu, Yunhui
core
A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms
FEBS Open Bio, EarlyView.We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
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FEBS Open Bio, EarlyView.Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
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Generalization of Fixed Point Theorem for φ- Contraction Mapping of a Fuzzy b- Metric Space
Ibn Al-Haitham Journal for Pure and Applied SciencesLet (X,W,T) be a fuzzy b- metric space, where X is a non-empty set, W is a fuzzy set on X×X×(0,∞) to [0,1], and T is a continuous t-norm, and let a function φ:[0,1]→[0,1] satisfies the following conditions: The function φ is strictly decreasing and ...
Russll Abdul Kadhim Mohammed +1 more
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FEBS Open Bio, EarlyView.This research protocol outlines a workflow for nuclear magnetic resonance (NMR)‐based metabolomics in the agri‐food sector. Using two case studies—strawberry leaves (solid matrix) and wine (liquid matrix)—it details the procedures for sample preparation, data acquisition, and processing.
Andrea Fernández‐Veloso +4 more
wiley +1 more source