Results 71 to 80 of about 167,627 (310)

Respiratory chain complexes in dynamic mitochondria display a patchy distribution in life cells

, 2010
Background: Mitochondria, the main suppliers of cellular energy, are dynamic organelles that fuse and divide frequently. Constraining these processes impairs mitochondrial is closely linked to certain neurodegenerative diseases.
Strecker, V., Busch, K., Winfried Haase, Wittig, I., Bereiter-Hahn, Jürgen, Haase, W., Karin Busch, Joos, Friederike, Ilka Wittig, Britta Muster, Jürgen Bereiter-Hahn, Wittig, Ilka, Wladislaw Kohl, Valentina Strecker, Busch, Karin, Haase, Winfried, Joos, F., Muster, Britta, Kohl, W., Strecker, Valentina, Friederike Joos, Muster, B., Bereiter-Hahn, J., Kohl, Wladislaw   +23 more
core   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

The complete mitochondrial genome of the hybrid of Hoplobatrachus chinensis (♀)×H. rugulosus (♂) and its phylogeny

Mitochondrial DNA. Part B. Resources, 2018
The complete mitochondrial genome sequence of the hybrid of Hoplobatrachus chinensis (♀) × H. rugulosus (♂) was obtained in this study. The circular mitochondrial genome was 20,282 bp in length (including extra ND5 genes).
Yu-Ting Cai, Lin Ma, Chen-Jie Xu, Peng Li, Jia-Yong Zhang, Kenneth B. Storey, Dan-Na Yu   +6 more
doaj   +1 more source

Mitochondrial Genomic Landscape: A Portrait of the Mitochondrial Genome 40 Years after the First Complete Sequence

Life, 2021
Notwithstanding the initial claims of general conservation, mitochondrial genomes are a largely heterogeneous set of organellar chromosomes which displays a bewildering diversity in terms of structure, architecture, gene content, and functionality.
Alessandro Formaggioni, A. Luchetti, Federico Plazzi   +2 more
semanticscholar   +1 more source

GATA4‐Driven Transcription of HtrA1 Promotes Cellular Senescence in Ménière's Disease and Age‐Related Audio‐Vestibular Dysfunction

Advanced Science, EarlyView.
This study identifies the HDAC6/GATA4/HtrA1 axis as a critical driver of cellular senescence in the inner ear. GATA4 nuclear translocation, facilitated by HDAC6 downregulation, transcriptionally activates HtrA1, promoting hair cell senescence, SASP, and audio‐vestibular dysfunction in models of Ménière's disease and age‐related audio‐vestibular ...
Na Zhang, Na Li, Yan Wang, Jing Zhang, Jiahui Liu, Lei Chen, Yongdong Song, Yurong Mu, Yuechen Han, Yafeng Lyu, Xiaofei Li, Hanyue Wang, Jing Wang, Yao Lu, Zhaomin Fan, Daogong Zhang, Haibo Wang   +16 more
wiley   +1 more source

The complete mitochondrial genome of the intertidal spider (Desis jiaxiangi) provides novel insights into the adaptive evolution of the mitogenome and the evolution of spiders

BMC Ecology and Evolution, 2021
Background Although almost all extant spider species live in terrestrial environments, a few species live fully submerged in freshwater or seawater. The intertidal spiders (genus Desis ) built silk nests within coral crevices can survive submerged in ...
Fan Li, Yunyun Lv, Zheng Wen, Chao Bian, Xinhui Zhang, Shengtao Guo, Q. Shi, Daiqin Li   +7 more
semanticscholar   +1 more source

Unraveling the Molecular Mechanisms Underlying Spontaneous Multipolar Mitosis Through CIN‐seq

Advanced Science, EarlyView.
Multipolar mitosis, a hallmark of chromosomal instability (CIN), drives tumor heterogeneity but is challenging to study in live cells. Using CIN‐seq, a single‐cell multiomics method, we profiled rare CIN events and identified mechanisms associated with viable multipolar mitosis, including PTEN attenuation, Rho GTPase‐driven cytokinesis failure, and ...
Pin‐Rui Su, Ting‐Chun Chou, Maria Teresa López‐Cascales, Junfeng Huang, Tsai‐Ying Chen, Sjoukje van Wieren, Chan Li, Cecile Beerens, Li You, Jelle Storteboom, Miao‐Ping Chien   +10 more
wiley   +1 more source

The complete mitochondrial genome sequence of Boechera stricta

Mitochondrial DNA. Part B. Resources, 2018
Boechera stricta (B. stricta) is a wild relative of Arabidopsis, occurring in mostly montane regions of western North America. In this article, we assembled the complete mitochondrial (mt) DNA sequence of B.
Junji Li, Changwei Bi, Jing Tu, Zuhong Lu   +3 more
doaj   +1 more source

Analysis of Complete Mitochondrial Genome of Bohadschia argus (Jaeger, 1833) (Aspidochirotida, Holothuriidae)

Animals, 2022
Simple Summary Mitochondrial genomes are a type of specific genetic marker, characterized in most animals by a rapid mutation rate, high copy numbers and the absence of genetic recombination.
Bo Ma, Zhuobo Li, Ying Lv, Z. E., Jianxiang Fang, C. Ren, Peng Luo, Chao-qun Hu   +7 more
semanticscholar   +1 more source